Publication:
Construction of miRNA-mRNA networks for the identification of lung cancer biomarkers in liquid biopsies.

Simple item page
dc.contributor.authorEspinosa-Garcia, Elena
dc.contributor.authorArroyo-Varela, Macarena
dc.contributor.authorLarrosa-Jimenez, Rafael
dc.contributor.authorGomez-Maldonado, Josefa
dc.contributor.authorCobo-Dols, Manuel Angel
dc.contributor.authorClaros, M Gonzalo
dc.contributor.authorBautista-Moreno, Rocio
dc.contributor.funderNeumosur
dc.contributor.funderSEPAR
dc.date.accessioned2023-05-03T14:04:35Z
dc.date.available2023-05-03T14:04:35Z
dc.date.issued2022-10-13
dc.description.abstractLung cancer (LC) is the most common cause of cancer death worldwide mostly due to the low survival rate: 75% of cases are identified in advanced stages. In this study, the list of useful biomarkers to make an early diagnosis using liquid biopsies was expanded. A total of 30 samples of LC were analyzed to define potential miRNA biomarkers in liquid biopsies for LC. The biomarkers have been identified in interaction networks miRNA-mRNA. The potential biomarkers have been then validated in large cohorts. A total of 15 candidate miRNAs, that regulate the repression of 30 mRNAs, have been identified as a specific functional interaction network for squamous carcinoma, while the specific functional interaction network of adenocarcinoma consists of four candidate miRNAs that seem to handle the repression of five mRNA. Inspection of expression levels in larger cohorts validates the usefulness of the 11 candidates as biomarkers in liquid biopsies. The 11 candidate miRNAs found could be utilized to form diagnostic predictive biomarkers for LC in liquid biopsies.
dc.description.versionSi
dc.identifier.citationEspinosa Garcia E, Arroyo Varela M, Larrosa Jimenez R, Gomez-Maldonado J, Cobo Dols MA, Claros MG, et al. Construction of miRNA-mRNA networks for the identification of lung cancer biomarkers in liquid biopsies. Clin Transl Oncol. 2023 Mar;25(3):643-652
dc.identifier.doi10.1007/s12094-022-02969-7
dc.identifier.essn1699-3055
dc.identifier.pmcPMC9941226
dc.identifier.pmid36229739
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9941226/pdf
dc.identifier.unpaywallURLhttps://link.springer.com/content/pdf/10.1007/s12094-022-02969-7.pdf
dc.identifier.urihttp://hdl.handle.net/10668/21230
dc.issue.number3
dc.journal.titleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
dc.journal.titleabbreviationClin Transl Oncol
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number643-652
dc.provenanceRealizada la curación de contenido 19/03/2025
dc.publisherSpringer
dc.pubmedtypeJournal Article
dc.relation.projectID5/2017
dc.relation.projectID697/2018
dc.relation.projectIDRealizada la curación de contenido 19/03/2025
dc.relation.publisherversionhttps://dx.doi.org/10.1007/s12094-022-02969-7
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiomarker
dc.subjectHigh-throughput sequencing
dc.subjectLung cancer
dc.subjectRNA-seq
dc.subjectmiRNA
dc.subject.decsBiopsia Líquida
dc.subject.decsARN Mensajero
dc.subject.decsRepresión Psicológica
dc.subject.decsTasa de Supervivencia
dc.subject.decsCarcinoma de Células Escamosas
dc.subject.decsAdenocarcinoma
dc.subject.decsNeoplasias Pulmonares
dc.subject.meshHumans
dc.subject.meshMicroRNAs
dc.subject.meshBiomarkers, Tumor
dc.subject.meshRNA, Messenger
dc.subject.meshGene Expression Regulation, Neoplastic
dc.subject.meshLung Neoplasms
dc.subject.meshLung
dc.subject.meshLiquid Biopsy
dc.titleConstruction of miRNA-mRNA networks for the identification of lung cancer biomarkers in liquid biopsies.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number25
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 2 of 2
Thumbnail Image
Name:
PMC9941226.pdf
Size:
2.56 MB
Format:
Adobe Portable Document Format
Download
No Thumbnail Available
Name:
Espinosa-Garcia_ConstructionOf_MaterialSuplementario.zip
Size:
466.06 KB
Format:
Download

Collections

SAS - Hospital Regional Universitario de Málaga
Instituto de Investigación Biomédica de Málaga - Plataforma Bionand (IBIMA)

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía