Publication:
Effect of functionalized PHEMA micro- and nano-particles on the viscoelastic properties of fibrin-agarose biomaterials.

dc.contributor.authorScionti, Giuseppe
dc.contributor.authorRodriguez-Arco, Laura
dc.contributor.authorLopez-Lopez, Modesto T
dc.contributor.authorMedina-Castillo, Antonio L
dc.contributor.authorGarzón, Ingrid
dc.contributor.authorAlaminos, Miguel
dc.contributor.authorToledano, Manuel
dc.contributor.authorOsorio, Raquel
dc.date.accessioned2023-01-25T10:01:01Z
dc.date.available2023-01-25T10:01:01Z
dc.date.issued2017-11-17
dc.description.abstractTwo types of PHEMA-based particles, exhibiting either carboxyl or tertiary ammine functional groups, were incorporated to fibrin-agarose (FA) hydrogels, and the effect of the addition of these synthetic particles on the viscoelastic and microstructural properties of the biomaterials was evaluated. Experimental results indicated that the incorporation of both types of polymeric particles to FA scaffolds was able to improve the biomechanical properties of the biomaterials under steady state and oscillatory shear stresses, resulting in scaffolds characterized by higher values of the storage, loss, and shear moduli. In addition, the microstructural evaluation of the scaffolds showed that the nanoparticles exhibiting carboxyl functional groups were homogeneously distributed across the fibrous network of the hydrogels. The addition of both types of artificial polymeric particles was able to enhance the viscoelastic properties of the FA hydrogels, allowing the biomaterials to reach levels of mechanical consistency under shear stresses in the same range of some human native soft tissues, which could allow these biomaterials to be used as scaffolds for new tissue engineering applications. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 738-745, 2018.
dc.identifier.doi10.1002/jbm.a.36275
dc.identifier.essn1552-4965
dc.identifier.pmid29052310
dc.identifier.unpaywallURLhttps://upcommons.upc.edu/bitstream/2117/116135/3/Scionti%20et%20al%202017%20JBMR-A%20revised.pdf
dc.identifier.urihttp://hdl.handle.net/10668/11705
dc.issue.number3
dc.journal.titleJournal of biomedical materials research. Part A
dc.journal.titleabbreviationJ Biomed Mater Res A
dc.language.isoen
dc.organizationInstituto de Investigación Biosanitaria ibs. GRANADA
dc.page.number738-745
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectagarose
dc.subjectfibrin
dc.subjectfunctionalized particles
dc.subjecthydrogel
dc.subjectscaffold
dc.subject.meshBiocompatible Materials
dc.subject.meshBiomechanical Phenomena
dc.subject.meshElasticity
dc.subject.meshFibrin
dc.subject.meshHydrogels
dc.subject.meshNanoparticles
dc.subject.meshPolyhydroxyethyl Methacrylate
dc.subject.meshSepharose
dc.subject.meshShear Strength
dc.subject.meshViscosity
dc.titleEffect of functionalized PHEMA micro- and nano-particles on the viscoelastic properties of fibrin-agarose biomaterials.
dc.typeresearch article
dc.type.hasVersionSMUR
dc.volume.number106
dspace.entity.typePublication

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