Publication:
COVID-19  vaccination in patients receiving allergen immunotherapy (AIT) or biologicals-EAACI recommendations.

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Date

2022-08-06

Authors

Jutel, Marek
Torres, Maria J
Palomares, Oscar
Akdis, Cezmi A
Eiwegger, Thomas
Untersmayr, Eva
Barber, Domingo
Zemelka-Wiacek, Magdalena
Kosowska, Anna
Palmer, Elizabeth

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John Wiley & Sons
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Abstract

Immune modulation is a key therapeutic approach for allergic diseases, asthma and autoimmunity. It can be achieved in an antigen-specific manner via allergen immunotherapy (AIT) or in an endotype-driven approach using biologicals that target the major pathways of the type 2 (T2) immune response: immunoglobulin (Ig)E, interleukin (IL)-5 and IL-4/IL-13 or non-type 2 response: anti-cytokine antibodies and B-cell depletion via anti-CD20. Coronavirus disease 2019 (COVID-19) vaccination provides an excellent opportunity to tackle the global pandemics and is currently being applied in an accelerated rhythm worldwide. The vaccine exerts its effects through immune modulation, induces and amplifies the response against the severe acute respiratory syndrome coronavirus (SARS-CoV-2). Thus, as there may be a discernible interference between these treatment modalities, recommendations on how they should be applied in sequence are expected. The European Academy of Allergy and Clinical Immunology (EAACI) assembled an expert panel under its Research and Outreach Committee (ROC). This expert panel evaluated the evidence and have formulated recommendations on the administration of COVID-19 vaccine in patients with allergic diseases and asthma receiving AIT or biologicals. The panel also formulated recommendations for COVID-19 vaccine in association with biologicals targeting the type 1 or type 3 immune response. In formulating recommendations, the panel evaluated the mechanisms of COVID-19 infection, of COVID-19 vaccine, of AIT and of biologicals and considered the data published for other anti-infectious vaccines administered concurrently with AIT or biologicals.

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MeSH Terms

Allergens
Asthma
Biological Products
COVID-19
COVID-19 Vaccines
Desensitization, Immunologic
Humans
Hypersensitivity
Immunoglobulin E
SARS-CoV-2
Vaccination

DeCS Terms

Vacunas contra la COVID-19
Antígenos
Anticuerpos
Hipersensibilidad
Desensibilización Inmunológica
Vacunación
Autoinmunidad

CIE Terms

Keywords

Covid-19, Allergen, Allergy, Biologicals, Immunotherapy, mRNA vaccines

Citation

Jutel M, Torres MJ, Palomares O, Akdis CA, Eiwegger T, Untersmayr E, et al. COVID-19 vaccination in patients receiving allergen immunotherapy (AIT) or biologicals-EAACI recommendations. Allergy. 2022 Aug;77(8):2313-2336