Publication: Immune checkpoint inhibitors-associated thrombosis in patients with lung cancer and melanoma: a study of the Spanish society of medical oncology (SEOM) thrombosis and cancer group.
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Date
2022-06-06
Authors
Cánovas, Manuel Sánchez
Garay, David Fernández
Moran, Laura Ortega
Pérez, Jaime Rubio
Rubio, Carlos Miguel Guirao
de Mena, Miriam Lobo
Portero, Berta Obispo
Castro, Jesús Brenes
Lage, Yolanda
Lavin, Diego Cacho
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Abstract
Immune Checkpoint Inhibitors (ICI) can be associated with thrombotic events, both venous and arterial (VTE/AT). However, there is a paucity of information regarding patients in routine clinical practice. Retrospective, multicenter study promoted by the Thrombosis and Cancer Section of the Spanish Society of Medical Oncology (SEOM). Patients with melanoma and lung cancer who initiated ICI between 01/01/2015 and 31/12/2019 were recruited. Minimum follow-up was 6 months (unless it was not possible because of death). The primary objective was to calculate the incidence of ICI-associated VTE/AT and the secondary objectives included to analyze its impact on survival and to identify predictor variables for VTE/AT. 665 patients with lung cancer were enrolled. The incidence of VTE/AT during follow-up was 8.4%. Median overall survival (OS) was lower in the VTE/AT group (12 months 95% CI 4.84-19.16 vs. 19 months 95% CI 16.11-21.9; p = 0.0049). Neutrophil/lymphocyte ratio (NLR) and anemia upon initiation of IT, as well as a history of thrombosis between cancer diagnosis and the start of ICI, were predictive variables for developing of VTE/AT (p ICI increases the risk of VTE/AT in patients with lung cancer and melanoma, which impact OS.
Description
MeSH Terms
Humans
Immune Checkpoint Inhibitors
Lung Neoplasms
Medical Oncology
Melanoma
Prognosis
Retrospective Studies
Thrombosis
Venous Thromboembolism
Immune Checkpoint Inhibitors
Lung Neoplasms
Medical Oncology
Melanoma
Prognosis
Retrospective Studies
Thrombosis
Venous Thromboembolism
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Keywords
Cancer related thrombosis, Immune Checkpoint Inhibitors, Lung cancer, Melanoma