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New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp

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dc.contributor.authorStierhof, Marc
dc.contributor.authorHansen, Kine Ostnes
dc.contributor.authorSharma, Mukesh
dc.contributor.authorFeussner, Klaus
dc.contributor.authorSubko, Karolina
dc.contributor.authorDiaz-Rullo, Fernando Fernandez
dc.contributor.authorIsaksson, Johan
dc.contributor.authorPerez-Victoria, Ignacio
dc.contributor.authorClarke, David
dc.contributor.authorHansen, Espen
dc.contributor.authorJaspars, Marcel
dc.contributor.authorTabudravu, Jioji N.
dc.contributor.authoraffiliation[Stierhof, Marc] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland
dc.contributor.authoraffiliation[Subko, Karolina] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland
dc.contributor.authoraffiliation[Jaspars, Marcel] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland
dc.contributor.authoraffiliation[Tabudravu, Jioji N.] Univ Aberdeen, Dept Chem, Marine Biodiscovery Ctr, Aberdeen AB24 3UE, Scotland
dc.contributor.authoraffiliation[Hansen, Kine Ostnes] UiT Arctic Univ Norway, Marbio, N-9037 Tromso, Norway
dc.contributor.authoraffiliation[Hansen, Espen] UiT Arctic Univ Norway, Marbio, N-9037 Tromso, Norway
dc.contributor.authoraffiliation[Sharma, Mukesh] Univ South Pacific, Fac Sci Technol & Environm, Inst Appl Sci, POB 1168, Suva, Fiji
dc.contributor.authoraffiliation[Feussner, Klaus] Univ South Pacific, Fac Sci Technol & Environm, Inst Appl Sci, POB 1168, Suva, Fiji
dc.contributor.authoraffiliation[Diaz-Rullo, Fernando Fernandez] Univ Aberdeen, Inst Med Sci, Aberdeen AB24 3UE, Scotland
dc.contributor.authoraffiliation[Isaksson, Johan] UiT Arctic Univ Norway, Dept Chem, N-9037 Tromso, Norway
dc.contributor.authoraffiliation[Perez-Victoria, Ignacio] Fdn MEDINA, Parque Tecnol Salud,Ave Conocimiento 34, Granada 18016, Spain
dc.contributor.authoraffiliation[Clarke, David] Univ Edinburgh, Sch Chem, Joseph Black Bldg,David Brewster Rd, Edinburgh EH9 3FJ, Midlothian, Scotland
dc.contributor.funderEU
dc.contributor.funderNCDDG
dc.date.accessioned2023-02-12T02:21:10Z
dc.date.available2023-02-12T02:21:10Z
dc.date.issued2016-11-03
dc.description.abstractFour new callipeltin A derivatives (N-Q) have been isolated from the Solomon Island marine sponge Asteropus sp. Their structures were established by spectroscopic techniques followed by acid hydrolysis and derivatisation of the free amino acids, and subsequent LCMS analysis of the derivatives. The compounds were evaluated for their activity against cancer cell lines A2058 (melanoma), HT-29 (colorectal adenocarcinoma) and MCF-7 (breast adenocarcinoma) and non-malignant MRC-5 fibroblast cells. While the acyclic callipeltins P and Q were inactive the cyclic callipeltins N and O showed significant cytotoxicity against all exposed cell lines with IC50 values as low as 0.16 mu M confirming the role of cyclic configuration in biological activity. (C) 2016 Elsevier Ltd. All rights reserved.
dc.identifier.doi10.1016/j.tet.2016.09.016
dc.identifier.issn0040-4020
dc.identifier.unpaywallURLhttp://hdl.handle.net/2164/9297
dc.identifier.urihttp://hdl.handle.net/10668/18887
dc.identifier.wosID386404600003
dc.issue.number44
dc.journal.titleTetrahedron
dc.journal.titleabbreviationTetrahedron
dc.language.isoen
dc.organizationFundación MEDINA (Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía)
dc.organizationFundación MEDINA
dc.page.number6929-6934
dc.publisherPergamon-elsevier science ltd
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCallipeltin
dc.subjectAsteropus
dc.subjectNMR
dc.subjectLCMS
dc.subjectDerivatisation
dc.subjectAntiproliferative activity
dc.subjectPapua-new-guinea
dc.subjectAntifungal peptides
dc.subjectCyclic depsipeptide
dc.subjectTheonella-swinhoei
dc.subjectLatrunculia sp
dc.titleNew cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp
dc.typeresearch article
dc.type.hasVersionSMUR
dc.volume.number72
dc.wostypeArticle
dspace.entity.typePublication

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