Publication: Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects
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Date
2021-09-20
Authors
Sánchez-Díaz, Manuel
López-Delgado, David
Montero-Vílchez, Trinidad
Salvador-Rodríguez, Luis
Molina-Leyva, Alejandro
Tercedor-Sánchez, Jesús
Arias-Santiago, Salvador
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Abstract
Oral minoxidil is an approved treatment for high blood pressure which is also used as an off-label drug for alopecia. Knowledge about the effects of systemic minoxidil in the paediatric population is limited. A retrospective case series study of paediatric patients with history of systemic minoxidil intake due to contaminated sets of omeprazole was performed to describe side effects of high dose oral minoxidil intake in children. Twenty patients aged between 2 months and 13 years joined the study. They had received high doses of oral minoxidil (mean dose 0.90 mg/kg/day) during a mean time of 38.3 days. Hypertrichosis appeared in 65%, with a mean latency time of 24.31 days. Treatment time was associated with the appearance of hypertrichosis (p < 0.05). Most common initial zone of hypertrichosis was the face. Systemic effects developed in 15%, with no cases of severe disorders. The present study shows a novel insight into the side effects of high doses of oral minoxidil in children.
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MeSH Terms
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Persons::Persons::Age Groups::Child
Medical Subject Headings::Persons::Persons::Age Groups::Infant
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperidines::Minoxidil
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Prescriptions::Off-Label Use
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Hair Diseases::Hypertrichosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies
Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Hair Diseases::Hypotrichosis::Alopecia
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Sulfoxides::2-Pyridinylmethylsulfinylbenzimidazoles::Omeprazole
Medical Subject Headings::Persons::Persons::Age Groups::Child
Medical Subject Headings::Persons::Persons::Age Groups::Infant
Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Piperidines::Minoxidil
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Prescriptions::Off-Label Use
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Hair Diseases::Hypertrichosis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies
Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension
Medical Subject Headings::Diseases::Skin and Connective Tissue Diseases::Skin Diseases::Hair Diseases::Hypotrichosis::Alopecia
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Sulfur Compounds::Sulfoxides::2-Pyridinylmethylsulfinylbenzimidazoles::Omeprazole
DeCS Terms
CIE Terms
Keywords
Minoxidil, Hypertrichosis, Alopecia, Children, Hipertricosis, Niño, Pacientes
Citation
Sánchez-Díaz M, López-Delgado D, Montero-Vílchez T, Salvador-Rodríguez L, Molina-Leyva A, Tercedor-Sánchez J, et al. Systemic Minoxidil Accidental Exposure in a Paediatric Population: A Case Series Study of Cutaneous and Systemic Side Effects. J Clin Med. 2021 Sep 20;10(18):4257