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Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study.

dc.contributor.authorCarmona-Segovia, Ada-Del-Mar
dc.contributor.authorDoncel-Abad, Maria Victoria
dc.contributor.authorBecerra-Muñoz, Victor M
dc.contributor.authorRodriguez-Capitan, Jorge
dc.contributor.authorSabatel-Perez, Fernando
dc.contributor.authorFlores-Lopez, Maria
dc.contributor.authorSanchez-Quintero, Maria Jose
dc.contributor.authorMedina-Vera, Dina
dc.contributor.authorMolina-Ramos, Ana Isabel
dc.contributor.authorEl-Bekay, Rajaa
dc.contributor.authorMorales-Asencio, Jose Miguel
dc.contributor.authorAngullo-Gomez, Maria
dc.contributor.authorGarcia-Rodriguez, Luis
dc.contributor.authorPalma-Marti, Lucia
dc.contributor.authorPavon-Moron, Francisco Javier
dc.contributor.authorJimenez-Navarro, Manuel F
dc.contributor.funderFundación Andaluza de Cardiología
dc.contributor.funderConsejería de Salud y Familias, Junta de Andalucía
dc.contributor.funderEuropean Regional Development Funds/European Social Fund (ERDF/ESF)
dc.contributor.funderConsejería de Economía, Conocimiento, Empresas y Universidad
dc.contributor.funderServicio Andaluz de Salud
dc.date.accessioned2023-05-03T13:31:15Z
dc.date.available2023-05-03T13:31:15Z
dc.date.issued2022-02-28
dc.description.abstractThe incidence of acute coronary syndrome is rising in step with the growth of life expectancy. An increase in the age of patients with coronary artery disease has been related to in-hospital mortality, which has seen an upsurge over a short period of time. However, there is no consensus about the percutaneous coronary angioplasty strategy to follow for older patients with multivessel coronary artery disease (MVCAD). Complete revascularisation (CR) or incomplete revascularisation (ICR) strategy depends on prognosis but this has not yet been accurately described because of geriatric conditions and comorbidities. The aim of this study is to evaluate changes of clinical and biochemical parameters in older patients with MVCAD undergoing revascularisation and to establish a prognostic stratification model for CR and ICR. This observational, longitudinal, prospective study will include 150 patients with MVCAD and subsequent revascularisation who attend the Hospital Universitario Virgen de la Victoria (Málaga, Spain). Because of the dropout rates, 180 patients will be recruited at the beginning. Sociodemographic characteristics, clinical and angiographic parameters, and biochemical variables, such as cardiovascular, metabolic, inflammatory, stress oxidative biomarkers, will be collected in the admission for coronary revascularisation and three follow-ups at 6, 12 and 18 months. Statistical analyses will be conducted with these data using CR and ICR as the primary exposure variable. Relevant explanatory variables will be selected from a predictive model for their inclusion in a prognostic stratification model. The primary outcome measures will be major adverse cardiovascular events. Protocols and patient information have been approved by the regional research ethics committee (CEIm Provincial de Málaga-PEIBA (PI0131/2020). The results will be disseminated in international peer-reviewed journals, presented at conferences in Cardiology and Gerontology, and sent to participants, medical and health service managers, clinicians and other researchers.
dc.description.versionSi
dc.identifier.citationCarmona-Segovia ADM, Doncel-Abad MV, Becerra-Muñoz VM, Rodríguez-Capitán J, Sabatel-Pérez F, Flores-López M, et al. Prognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study. BMJ Open. 2022 Feb 28;12(2):e058042
dc.identifier.doi10.1136/bmjopen-2021-058042
dc.identifier.essn2044-6055
dc.identifier.pmcPMC8886411
dc.identifier.pmid35228293
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8886411/pdf
dc.identifier.unpaywallURLhttps://bmjopen.bmj.com/content/bmjopen/12/2/e058042.full.pdf
dc.identifier.urihttp://hdl.handle.net/10668/20142
dc.issue.number2
dc.journal.titleBMJ open
dc.journal.titleabbreviationBMJ Open
dc.language.isoen
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number6
dc.provenanceRealizada la curación de contenido 05/05/2025
dc.publisherBMJ Group
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.projectIDPI-131/2020
dc.relation.projectIDUMA-20-FEDERJA-074
dc.relation.publisherversionhttps://bmjopen.bmj.com/lookup/pmidlookup?view=long&pmid=35228293
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAdult cardiology
dc.subjectCoronary intervention
dc.subjectGeriatric medicine
dc.subjectIschaemic heart disease
dc.subjectMyocardial infarction
dc.subject.decsEnfermedad de la arteria coronaria
dc.subject.decsGeriatría
dc.subject.decsAngioplastia
dc.subject.decsEsperanza de vida
dc.subject.decsSíndrome Coronario Agudo
dc.subject.decsMortalidad hospitalaria
dc.subject.meshAged
dc.subject.meshAngioplasty, Balloon, Coronary
dc.subject.meshCoronary Artery Disease
dc.subject.meshHumans
dc.subject.meshMyocardial Infarction
dc.subject.meshObservational Studies as Topic
dc.subject.meshPrognosis
dc.subject.meshProspective Studies
dc.subject.meshTreatment Outcome
dc.titlePrognostic stratification of older patients with multivessel coronary artery disease treated with percutaneous transluminal coronary angioplasty based on clinical and biochemical measures: protocol for a prospective cohort study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number12
dspace.entity.typePublication

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