Publication:
Multi-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma.

Simple item page
dc.contributor.authorPeinado, Paola
dc.contributor.authorAndrades, Alvaro
dc.contributor.authorCuadros, Marta
dc.contributor.authorRodriguez, Maria Isabel
dc.contributor.authorCoira, Isabel F
dc.contributor.authorGarcia, Daniel J
dc.contributor.authorBenitez-Cantos, Maria S
dc.contributor.authorCano, Carlos
dc.contributor.authorZarzuela, Eduardo
dc.contributor.authorMuñoz, Javier
dc.contributor.authorLoidi, Claudia
dc.contributor.authorSaiz, Monica
dc.contributor.authorMedina, Pedro P
dc.date.accessioned2023-05-03T13:34:59Z
dc.date.available2023-05-03T13:34:59Z
dc.date.issued2022-03-17
dc.description.abstractSWI/SNF complexes are major targets of mutations in cancer. Here, we combined multiple "-omics" methods to assess SWI/SNF composition and aberrations in LUAD. Mutations in lung SWI/SNF subunits were highly recurrent in our LUAD cohort (41.4%), and over 70% of the mutations were predicted to have functional impact. Furthermore, SWI/SNF expression in LUAD suffered an overall repression that could not be explained exclusively by genetic alterations. Finally, SWI/SNF mutations were associated with poorer overall survival in TCGA-LUAD. We propose SWI/SNF-mutant LUAD as a separate clinical subgroup with practical implications.
dc.identifier.doi10.1186/s13148-022-01261-3
dc.identifier.essn1868-7083
dc.identifier.pmcPMC8931969
dc.identifier.pmid35300733
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8931969/pdf
dc.identifier.unpaywallURLhttps://clinicalepigeneticsjournal.biomedcentral.com/track/pdf/10.1186/s13148-022-01261-3
dc.identifier.urihttp://hdl.handle.net/10668/20358
dc.issue.number1
dc.journal.titleClinical epigenetics
dc.journal.titleabbreviationClin Epigenetics
dc.language.isoen
dc.organizationCentro Pfizer-Universidad de Granada-Junta de Andalucía de Genómica e Investigación Oncológica-GENYO
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number42
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectEpigenetics
dc.subjectLung adenocarcinoma
dc.subjectLung cancer
dc.subjectMulti-omics
dc.subjectPrognosis
dc.subjectSWI/SNF complex
dc.subject.meshAdenocarcinoma of Lung
dc.subject.meshDNA Methylation
dc.subject.meshDNA-Binding Proteins
dc.subject.meshHumans
dc.subject.meshLung Neoplasms
dc.subject.meshTranscription Factors
dc.titleMulti-omic alterations of the SWI/SNF complex define a clinical subgroup in lung adenocarcinoma.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number14
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
PMC8931969.pdf
Size:
1.29 MB
Format:
Adobe Portable Document Format
Download

Collections

Centro Pfizer-Andalucía de Genómica e Investigación Oncológica (GENYO)
Instituto de Investigación Biosanitaria de Granada (ibsGRANADA)

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía