Publication: Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study.
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2020-01-16
Authors
de la Cruz-Ares, Silvia
Cardelo, Magdalena P
Gutiérrez-Mariscal, Francisco M
Torres-Peña, José D
García-Rios, Antonio
Katsiki, Niki
Malagón, María M
López-Miranda, José
Pérez-Martínez, Pablo
Yubero-Serrano, Elena M
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Abstract
Endothelial dysfunction and intima-media thickness of common carotid arteries (IMT-CC) are considered subclinical markers of atherosclerotic cardiovascular disease (ASCVD). Advanced glycation end products (AGEs) are increased in type 2 diabetes mellitus (T2DM) patients, compared with non-diabetics, being implicated in micro- and macrovascular complications. Our aim was to compare serum AGEs levels and subclinical atherosclerotic markers between patients with established and newly diagnosed T2DM. Among 540 patients with T2DM and coronary heart disease from the CORDIOPREV study, 350 patients had established T2DM and 190 patients had newly diagnosed T2DM. Serum levels of AGEs (methylglyoxal (MG) and N-carboxymethyl lysine (CML)) and subclinical atherosclerotic markers (brachial flow-mediated vasodilation (FMD) and IMT-CC) were measured. AGEs levels (all p
Description
MeSH Terms
Biomarkers
Carotid Artery Diseases
Coronary Disease
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Diet, Healthy
Endothelium, Vascular
Female
Glycation End Products, Advanced
Humans
Lysine
Male
Middle Aged
Olive Oil
Pyruvaldehyde
Single-Blind Method
Vasodilation
Carotid Artery Diseases
Coronary Disease
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Diet, Healthy
Endothelium, Vascular
Female
Glycation End Products, Advanced
Humans
Lysine
Male
Middle Aged
Olive Oil
Pyruvaldehyde
Single-Blind Method
Vasodilation
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CIE Terms
Keywords
CORDIOPREV, N-carboxymethyl lysine, advanced glycation end products, endothelial dysfunction, flow-mediated vasodilation, intima-media thickness of common carotid arteries, methylglyoxal, type 2 diabetes mellitus