Publication: Aspirin for Evidence-Based Preeclampsia Prevention trial: effect of aspirin on length of stay in the neonatal intensive care unit.
No Thumbnail Available
Identifiers
Date
2018-03-02
Authors
Wright, David
Rolnik, Daniel L
Syngelaki, Argyro
de Paco Matallana, Catalina
Machuca, Mirian
de Alvarado, Mercedes
Mastrodima, Sofia
Tan, Min Yi
Shearing, Siobhan
Persico, Nicola
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Preeclampsia is a major pregnancy complication with adverse short- and long-term implications for both the mother and baby. Screening for preeclampsia at 11-13 weeks' gestation by a combination of maternal demographic characteristics and medical history with measurements of biomarkers can identify about 75% of women who develop preterm preeclampsia with delivery at We sought to examine the effect of prophylactic use of aspirin during pregnancy in women at high risk of preeclampsia on length of stay in the neonatal intensive care unit. This was a secondary analysis of data from the Aspirin for Evidence-Based Preeclampsia Prevention trial to assess evidence of differences in the effect of aspirin on length of stay in neonatal intensive care. Bootstrapping was used for the comparison of mean length of stay between the aspirin and placebo groups. Logistic regression was used to assess treatment effects on stay in the neonatal intensive care unit. In the trial there were 1620 participants and 1571 neonates were liveborn. The total length of stay in neonatal intensive care was substantially longer in the placebo than aspirin group (1696 vs 531 days). This is a reflection of significantly shorter mean lengths of stay in babies admitted to the neonatal intensive care unit from the aspirin than the placebo group (11.1 vs 31.4 days), a reduction of 20.3 days (95% confidence interval, 7.0-38.6; P = .008). Neonatal intensive care of babies born at In pregnancies at high risk of preeclampsia administration of aspirin reduces the length of stay in the neonatal intensive care unit by about 70%. This reduction could essentially be attributed to a decrease in the rate of births at
Description
MeSH Terms
Adult
Aspirin
Evidence-Based Medicine
Female
Humans
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Length of Stay
Logistic Models
Male
Odds Ratio
Platelet Aggregation Inhibitors
Pre-Eclampsia
Pregnancy
Aspirin
Evidence-Based Medicine
Female
Humans
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal
Length of Stay
Logistic Models
Male
Odds Ratio
Platelet Aggregation Inhibitors
Pre-Eclampsia
Pregnancy
DeCS Terms
CIE Terms
Keywords
Combined Multimarker Screening and Randomized Patient Treatment with Aspirin for Evidence-Based Preeclampsia Prevention trial, aspirin, first-trimester screening, health economics, neonatal intensive care, preeclampsia