Publication: Kounis Syndrome After Levofloxacin Intake: A Clinical Report and Cross-reactivity Study
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Date
2016-05-09
Authors
Garcia-Nunez, I
Algaba-Marmol, M. A.
Barasona-Villarejo, M. J.
Suarez-Vergara, M.
Espinola-Gonzalez, F.
Reina-Ariza, E.
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Esmon Publicidad
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Abstract
Kounis and Zavras [1] described a case of histamineinduced coronary artery spasm in 1991 and this concurrence of an acute coronary event with an acute allergic reaction (anaphylactic or anaphylactoid) is now known as Kounis
syndrome. It is due to extensive vasodilatation and low cardiac output. In the last 20 years, numerous factors have been implicated in Kounis syndrome, including drugs (eg, β-lactams [2], ibuprofen [3], contrast media), hymenoptera
stings, and food. We describe the case of a 35 year-old man who presented at
our allergy department with clinical symptoms (acute coronary syndrome and generalized angioedema with urticaria) and ST decline in several leads in an emergency electrocardiogram performed 30 minutes after the first intake of levofloxacin, which had been prescribed to treat sinusitis
Description
MeSH Terms
Hymenoptera
Ibuprofen
Acute Coronary Syndrome
Coronary Vasospasm
Cardiac Output, Low
Ibuprofen
Acute Coronary Syndrome
Coronary Vasospasm
Cardiac Output, Low
DeCS Terms
Electrocardiografía
Síndrome coronario agudo
Enfermedad aguda
Síndrome de Kounis
Síndrome coronario agudo
Enfermedad aguda
Síndrome de Kounis
CIE Terms
Keywords
Kounis syndrome, Levofloxacin, Ciprofloxacin, Basophil activation test, Specific IgE, Immediate hypersensitivity, Moxifloxacin, Quinolones, Área de Gestión Sanitaria de Osuna
Citation
García Núñez I, Algaba Mármol MA, Barasona Villarejo MJ, Suárez Vergara M, Espínola González F, Reina Ariza E. Kounis Syndrome After Levofloxacin Intake: A Clinical Report and Cross-reactivity Study. J Investig Allergol Clin Immunol. 2016;26(5):335-336