Publication:
Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion

Simple item page
dc.contributor.authorMuñoz-Fernández, Raquel
dc.contributor.authorDe La Mata, Claudia
dc.contributor.authorRequena, Francisco
dc.contributor.authorMartín, Francisco
dc.contributor.authorFernandez-Rubio, Pablo
dc.contributor.authorLlorca, Tatiana
dc.contributor.authorRuiz-Magaña, Maria José
dc.contributor.authorRuiz-Ruiz, Carmen
dc.contributor.authorOlivares, Enrique G.
dc.contributor.authoraffiliation[Munoz-Fernandez,R; De La Mata,C; Fernandez-Rubio,P; Llorca,T; Ruiz-Magana,MJ; Ruiz-Ruiz,C; Olivares,EG] Instituto de Biopatología y Medicina Regenerativa, Centro de Investigación Biomédica, Universidad de Granada, Granada, Spain. [Requena,F] Departamento de Estadística e Investigación Operativa, Universidad de Granada, Granada, Spain. [Martín,F] Human DNA Variability Department, GENYO - Centre for Genomic and Oncological Research (Pfizer/University of Granada/Andalusian Regional Government), PTS Granada, Granada, Spain. [Ruiz-Ruiz,C; Olivares,EG] Departamento de Bioquímica y Biología Molecular III e Inmunología, Facultad de Medicina, Universidad de Granada, Granada, Spain. [Olivares,EG] Unidad de Gestión Clínica Laboratorios, Hospital Universitario San Cecilio, Granada, Spain.
dc.contributor.funderThis work was supported by the Plan Estatal de Investigación Científica y Técnica y de Innovación 2013–2016, ISCIII-Subdirección General de Evaluación y Fomento de la Investigación, the Ministerio de Economía y Competitividad, Spain (Grant PI16/01642) and European Regional Development Fund (ERDF/FEDER funding), the European Community, and the Cátedra de Investigación Antonio Chamorro–Alejandro Otero, Universidad de Granada (CACH2017-1).
dc.date.accessioned2020-07-24T10:41:19Z
dc.date.available2020-07-24T10:41:19Z
dc.date.issued2019-06-14
dc.description.abstractHuman decidual stromal cells (DSCs) are involved in the maintenance and development of pregnancy, in which they play a key role in the induction of immunological maternal-fetal tolerance. Precursors of DSCs (preDSCs) are located around the vessels, and based on their antigen phenotype, previous studies suggested a relationship between preDSCs and mesenchymal stromal/stem cells (MSCs). This work aimed to further elucidate the MSC characteristics of preDSCs.es_ES
dc.description.versionYeses_ES
dc.identifier.citationMuñoz-Fernández R, De La Mata C, Requena F, Martín F, Fernandez-Rubio P, Llorca T, et al. Human predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortion. Stem Cell Res Ther. 2019 Jun 14;10(1):177.es_ES
dc.identifier.doi10.1186/s13287-019-1284-zes_ES
dc.identifier.essn1757-6512
dc.identifier.pmcPMC6567662
dc.identifier.pmid31200769es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3150
dc.journal.titleStem Cell Research & Therapy
dc.language.isoen
dc.page.number13 p.
dc.publisherBioMed Central Ltd.es_ES
dc.relation.publisherversionhttps://stemcellres.biomedcentral.com/articles/10.1186/s13287-019-1284-zes_ES
dc.rights.accessRightsopen access
dc.subjectClone cellses_ES
dc.subjectDeciduaes_ES
dc.subjectImmune tolerancees_ES
dc.subjectImmunotherapyes_ES
dc.subjectMesenchymal stromal cellses_ES
dc.subjectPredecidual stromal cellses_ES
dc.subjectRecurrent abortiones_ES
dc.subjectCélulas clonaleses_ES
dc.subjectTolerancia inmunológicaes_ES
dc.subjectInmunoterapiaes_ES
dc.subjectCélulas madre mesenquimatosases_ES
dc.subjectAborto habituales_ES
dc.subject.meshMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Abortion, Spontaneous::Abortion, Habituales_ES
dc.subject.meshMedical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Pregnancy Complications::Abortion, Spontaneouses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiationes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cells, Culturedes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Embryonic Structures::Placenta::Deciduaes_ES
dc.subject.meshMedical Subject Headings::Diseases::Animal Diseases::Disease Models, Animales_ES
dc.subject.meshMedical Subject Headings::Anatomy::Urogenital System::Genitalia::Genitalia, Female::Uterus::Endometriumes_ES
dc.subject.meshMedical Subject Headings::Check Tags::Femalees_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Mesenchymal Stem Cell Transplantationes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Micees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Reproduction::Pregnancyes_ES
dc.titleHuman predecidual stromal cells are mesenchymal stromal/stem cells and have a therapeutic effect in an immune-based mouse model of recurrent spontaneous abortiones_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
MuñozFernandez_HumanPredecidual.pdf
Size:
1.74 MB
Format:
Adobe Portable Document Format
Description:
Artículo publicado
Download

Collections

Centro Pfizer-Andalucía de Genómica e Investigación Oncológica (GENYO)
SAS - Hospital Universitario San Cecilio

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía