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Effects of pulsed electromagnetic field therapy on fatigue, walking performance, depression, and quality of life in adults with multiple sclerosis: a randomized placebo-controlled trial.

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2022-10-13

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Granja-Domínguez, Anabel
Hochsprung, Anja
Luque-Moreno, Carlos
Magni, Eleonora
Escudero-Uribe, Shahid
Heredia-Camacho, Beatriz
Izquierdo-Ayuso, Guillermo
Heredia-Rizo, Alberto Marcos

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Abstract

Multiple sclerosis has a great disability burden. Management of the disease is complex, and patients often seek new conservative approaches. To investigate the effect of low-frequency pulsed electromagnetic field (PEMF) therapy, compared to placebo, on the level of fatigue, walking performance, symptoms of depression, and quality of life (QOL) in patients with relapsing-remitting multiple sclerosis (RRMS). Forty-four adults with RRMS and minimal to significant disability were randomly assigned to a 4-week protocol using a PEMF or a placebo whole-body mat. The PEMF group were initially treated with 15Hz frequency, gradually increased to 30Hz (intensity between 25-35µT). The primary outcome was fatigue, assessed with the Fatigue Severity Scale (FSS) and the Modified Fatigue Impact Scale (MFIS). Secondary measures included walking function (GAITRite system and Timed 25-Foot Walk test), the Beck Depression Inventory-II, and the Multiple Sclerosis International Quality of Life Questionnaire. Data were collected at baseline, after intervention, and at 3-months post-intervention (follow-up). There were no differences between groups for changes in fatigue symptoms from baseline to end of intervention (mean and 95% confidence interval FSS: -0.6, 95%CI: -1.3, 0.1; MFIS: -5.4, 95% CI: -15.1, 4.4) or at follow-up (FSS: -0.6, 95% CI: -1.4, 0.2; MFIS: -2.1, 95% CI: -10.9, 6.8). Similarly, both groups did not differ for any of the secondary outcomes at post-intervention or follow-up. Low-frequency PEMF therapy is no more effective than placebo to produce changes in fatigue, gait performance, severity of depression, and QOL in people with RRMS and minimal to significant disability.

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Adult
Humans
Quality of Life
Multiple Sclerosis
Electromagnetic Fields
Depression
Fatigue
Walking
Multiple Sclerosis, Relapsing-Remitting

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Keywords

Fatigue, Magnetic field therapy, Neurologic gait disorders, Placebo effect, Quality of life, Relapsing-remitting multiple sclerosis

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