Publication:
Extracellular Vesicle-Based Therapeutics for Heart Repair

Loading...
Thumbnail Image

Date

2021-02-25

Authors

Saludas, Laura
Oliveira, Cláudia C.
Roncal, Carmen
Ruiz-Villalba, Adrián
Prósper, Felipe
Garbayo, Elisa
Blanco-Prieto, María J.

Advisors

Journal Title

Journal ISSN

Volume Title

Publisher

MDPI
Metrics
Google Scholar
Export

Research Projects

Organizational Units

Journal Issue

Abstract

Extracellular vesicles (EVs) are constituted by a group of heterogeneous membrane vesicles secreted by most cell types that play a crucial role in cell-cell communication. In recent years, EVs have been postulated as a relevant novel therapeutic option for cardiovascular diseases, including myocardial infarction (MI), partially outperforming cell therapy. EVs may present several desirable features, such as no tumorigenicity, low immunogenic potential, high stability, and fine cardiac reparative efficacy. Furthermore, the natural origin of EVs makes them exceptional vehicles for drug delivery. EVs may overcome many of the limitations associated with current drug delivery systems (DDS), as they can travel long distances in body fluids, cross biological barriers, and deliver their cargo to recipient cells, among others. Here, we provide an overview of the most recent discoveries regarding the therapeutic potential of EVs for addressing cardiac damage after MI. In addition, we review the use of bioengineered EVs for targeted cardiac delivery and present some recent advances for exploiting EVs as DDS. Finally, we also discuss some of the most crucial aspects that should be addressed before a widespread translation to the clinical arena.

Description

MeSH Terms

Medical Subject Headings::Diseases::Cardiovascular Diseases
Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Myocardial Infarction
Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles::Cytoplasmic Vesicles::Transport Vesicles::Exosomes
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy
Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Biological Transport
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Communication
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Delivery Systems
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Biological Therapy::Cell- and Tissue-Based Therapy

DeCS Terms

CIE Terms

Keywords

Cardiovascular diseases, Myocardial infarction, Cardiac repair, Extracellular vesicles, Exosomes, Drug delivery, Cargo loading, Targeting, Enfermedades cardiovasculares, Infarto del miocardio, Vesículas extracelulares, Exosomas, Sistemas de liberación de medicamentos

Citation

Saludas L, Oliveira CC, Roncal C, Ruiz-Villalba A, Prósper F, Garbayo E, et al. Extracellular Vesicle-Based Therapeutics for Heart Repair. Nanomaterials. 2021 Feb 25;11(3):570.