Publication:
Isolated elevation of aspartate aminotransferase (AST) in an asymptomatic patient due to macro-AST.

dc.contributor.authorGonzález Raya, Arturo
dc.contributor.authorCoca Zúñiga, Ramón
dc.contributor.authorMartín Salido, Eva
dc.date.accessioned2023-01-25T10:23:19Z
dc.date.available2023-01-25T10:23:19Z
dc.date.issued2018-10-15
dc.description.abstractA rare and benign cause of isolated aspartate aminotransferase (AST) increase is due to the presence of macro aspartate aminotransferase (macro-AST). Macro-AST is not usually considered by clinicians, leading to a large number of unnecessary and even invasive tests before diagnosed. Most commonly used laboratory methods for detection of macro-enzymes are precipitation with polyethylene glycol (PEG), ultracentrifugation and gel filtration chromatography (GFC). We report a case of an asymptomatic patient with persistent isolated AST elevation. PEG precipitation and an alternative method based on the low stability of this macro-enzyme were performed on the patient serum. Macro-AST was early detected by the laboratory observing a significant decrease in AST concentrations when the serum is stored at 4ºC. Macro-AST detection based in this method can be very useful as screening, especially in those laboratories where other technologies are not available. Macro-AST must be considered as cause of unexplained isolated AST elevations before prior investigations to avoid the consequent cost and potential harm to the patient. In our case, early detection of macro-AST with this method avoided unnecessary treatment and invasive test such as liver biopsy.
dc.identifier.doi10.1002/jcla.22690
dc.identifier.essn1098-2825
dc.identifier.pmcPMC6818607
dc.identifier.pmid30320474
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6818607/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc6818607?pdf=render
dc.identifier.urihttp://hdl.handle.net/10668/13083
dc.issue.number2
dc.journal.titleJournal of clinical laboratory analysis
dc.journal.titleabbreviationJ Clin Lab Anal
dc.language.isoen
dc.organizationHospital Universitario Virgen de las Nieves
dc.organizationHospital Costa del Sol
dc.page.numbere22690
dc.pubmedtypeCase Reports
dc.pubmedtypeJournal Article
dc.rights.accessRightsopen access
dc.subjectaspartate aminotransferase
dc.subjectliver enzymes
dc.subjectmacro-AST
dc.subjectmacro-enzyme
dc.subjectpolyethylene glycol
dc.subject.meshAspartate Aminotransferases
dc.subject.meshAsymptomatic Diseases
dc.subject.meshBlood Chemical Analysis
dc.subject.meshDiagnosis, Differential
dc.subject.meshEnzyme Stability
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMiddle Aged
dc.subject.meshPolyethylene Glycols
dc.subject.meshTemperature
dc.titleIsolated elevation of aspartate aminotransferase (AST) in an asymptomatic patient due to macro-AST.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number33
dspace.entity.typePublication

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