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Clonal genetic evolution at relapse of favorable-risk acute myeloid leukemia with NPM1 mutation is associated with phenotypic changes and worse outcomes.

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dc.contributor.authorMartinez-Losada, Carmen
dc.contributor.authorSerrano-Lopez, Juana
dc.contributor.authorSerrano-Lopez, Josefina
dc.contributor.authorNoguera, Nelida I
dc.contributor.authorGarza, Eduardo
dc.contributor.authorPiredda, Liliana
dc.contributor.authorLavorgna, Serena
dc.contributor.authorConsalvo, Maria Antonietta Irno
dc.contributor.authorOttone, Tiziana
dc.contributor.authorAlfonso, Valentina
dc.contributor.authorPeinado, Juan Ramon
dc.contributor.authorGarcia-Ortiz, Maria Victoria
dc.contributor.authorMorales-Ruiz, Teresa
dc.contributor.authorJerez, Andres
dc.contributor.authorHurtado, Ana Maria
dc.contributor.authorMontesinos, Pau
dc.contributor.authorCervera, Jose
dc.contributor.authorSuch, Esperanza
dc.contributor.authorIbañez, Marian
dc.contributor.authorSempere, Amparo
dc.contributor.authorSanz, Miguel Angel
dc.contributor.authorLo-Coco, Francesco
dc.contributor.authorSanchez-Garcia, Joaquin
dc.contributor.funderFundación Alfonso Martin Escudero
dc.date.accessioned2023-01-25T10:06:12Z
dc.date.available2023-01-25T10:06:12Z
dc.date.issued2018-04-05
dc.description.abstractAcute myeloid leukemia (AML) is a dynamic disease caused by accumulating, somatically acquired driver mutations generating branching competing clones.1 In favorable-risk AML, high resolution genomic profiling by single nucleotide polymorphism array analysis of paired diagnostic-relapse NPM1mut and CBF AML samples revealed increased genomic complexity at relapse but most patients retained founding mutations.2,3 Furthermore, it has been extensively reported that phe notypic changes are commonly found at relapse in AML patients. It seems plausible that clonal evolution could be reflected in the phenotypic shifts of AML blast cells found at relapse, although the correlation with genetic clonal evolution has not been established
dc.identifier.citationMartínez-Losada C, Serrano-López J, Serrano-López J, Noguera NI, Garza E, Piredda L, et al. Clonal genetic evolution at relapse of favorable-risk acute myeloid leukemia with NPM1 mutation is associated with phenotypic changes and worse outcomes. Haematologica. 2018 Sep;103(9):e400-e403
dc.identifier.doi10.3324/haematol.2018.188433
dc.identifier.essn1592-8721
dc.identifier.pmcPMC6119134
dc.identifier.pmid29622659
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6119134/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.3324/haematol.2018.188433
dc.identifier.urihttp://hdl.handle.net/10668/12316
dc.issue.number9
dc.journal.titleHaematologica
dc.language.isoen
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba-IMIBIC
dc.organizationHospital Universitario Reina Sofía
dc.page.number400-403
dc.provenanceRealizada la curación de contenido 02/09/2024
dc.publisherFondazione Ferrata Storti
dc.pubmedtypeLetter
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.relation.publisherversionhttps://haematologica.org/article/view/8603
dc.rights.accessRightsopen access
dc.subjectBiomarkers, Tumor
dc.subjectClonal Evolution
dc.subjectDNA Mutational Analysis
dc.subjectGenetic Association Studies
dc.subjectGenome-Wide Association Study
dc.subject.decsFenotipo
dc.subject.decsLeucemia mieloide aguda
dc.subject.decsMutación
dc.subject.decsNucleofosmina
dc.subject.decsPronóstico
dc.subject.decsProteínas nucleares
dc.subject.decsRecurrencia
dc.subject.meshHumans
dc.subject.meshLeukemia, Myeloid, Acute
dc.subject.meshMutation
dc.subject.meshNuclear Proteins
dc.subject.meshNucleophosmin
dc.subject.meshPhenotype
dc.subject.meshPrognosis
dc.subject.meshRecurrence
dc.titleClonal genetic evolution at relapse of favorable-risk acute myeloid leukemia with NPM1 mutation is associated with phenotypic changes and worse outcomes.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number103
dspace.entity.typePublication

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