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Immediate improvement of left ventricular mechanics following transcatheter aortic valve replacement.

dc.contributor.authorLozano-Granero, Vanesa Cristina
dc.contributor.authorFernandez-Santos, Sara
dc.contributor.authorFernandez-Golfin, Covadonga
dc.contributor.authorPlaza-Martin, Maria
dc.contributor.authorde-la-Hera-Galarza, Jesus Maria
dc.contributor.authorFaletra, Francesco Fulvio
dc.contributor.authorSwaans, Martin J
dc.contributor.authorLopez-Fernandez, Teresa
dc.contributor.authorMesa, Dolores
dc.contributor.authorLa-Canna, Giovanni
dc.contributor.authorEcheverria-Garcia, Tomas
dc.contributor.authorHabib, Gilbert
dc.contributor.authorMartine-Monzonis, Amparo
dc.contributor.authorZamorano-Gomez, Jose Luis
dc.date.accessioned2023-01-25T10:20:28Z
dc.date.available2023-01-25T10:20:28Z
dc.date.issued2018-06-14
dc.description.abstractLeft ventricular (LV) mechanics are impaired in patients with severe aortic stenosis (AS). Transcatheter aortic valve replacement (TAVR) has become a widespread technique for patients with severe AS considered inoperable or high risk for traditional open-surgery. This procedure could have a positive impact in LV mechanics. The aim of this study was to evaluate the immediate effect of TAVR on LV function recovery, as assessed by myocardial deformation parameters. One-hundred twelve consecutive patients (81.4 ± 6.4 years, 50% female) from 10 centres in Europe with severe AS who successfully underwent TAVR with either a self-expanding CoreValve (Medtronic, Minneapolis, MN) or a mechanically expanded Lotus valve (Boston Scientific, Natick, MA) were enrolled in a prospective multi-center study. A complete echocardiographic examination was performed at baseline and immediately before discharge, including the assessment of LV strain using standard two-dimensional images. Echocardiographic examination with global longitudinal strain (GLS) quantification could be obtained in 92 patients, because of echocardiographic and logistic reasons. Between examinations, a modest statistically significant improvement in GLS could be seen (GLS% -15.00 ± 4.80 at baseline;-16.15 ± 4.97 at discharge, p = 0.028). In a stratified analysis, only women showed a significant improvement in GLS and a trend towards greater improvement in GLS according to severity of systolic dysfunction as measured by LV ejection fraction could be noted. Immediate improvement in GLS was appreciated after TAVR procedure. Whether this finding continues to be noted in a more prolonged follow-up and its clinical implications need to be assessed in further studies.
dc.description.versionSi
dc.identifier.citationLozano Granero VC, Fernández Santos S, Fernández-Golfín C, Plaza Martín M, de la Hera Galarza JM, Faletra FF, et al. Immediate improvement of left ventricular mechanics following transcatheter aortic valve replacement. Cardiol J. 2018;25(4):487-494
dc.identifier.doi10.5603/CJ.a2018.0066
dc.identifier.essn1898-018X
dc.identifier.pmid29924376
dc.identifier.unpaywallURLhttps://doi.org/10.5603/cj.a2018.0066
dc.identifier.urihttp://hdl.handle.net/10668/12619
dc.issue.number4
dc.journal.titleCardiology journal
dc.journal.titleabbreviationCardiol J
dc.language.isoen
dc.organizationHospital Universitario Reina Sofía
dc.page.number487-494
dc.provenanceRealizada la curación de contenido 11/08/2025
dc.publisherVia Medica
dc.pubmedtypeJournal Article
dc.pubmedtypeMulticenter Study
dc.relation.publisherversionhttps://journals.viamedica.pl/cardiology_journal/article/view/57020
dc.rights.accessRightsRestricted Access
dc.subjectAortic stenosis
dc.subjectEchocardiography
dc.subjectLeft ventricular mechanics
dc.subjectStrain
dc.subjectTranscatheter aortic valve replacement
dc.subject.decsEstenosis aórtica
dc.subject.decsReemplazo de la válvula aórtica transcatéter
dc.subject.decsVentrículo izquierdo
dc.subject.decsDisfunción sistólica
dc.subject.decsEcocardiografía
dc.subject.decsDeformación miocárdica
dc.subject.meshAged, 80 and over
dc.subject.meshAortic Valve Stenosis
dc.subject.meshEchocardiography
dc.subject.meshFemale
dc.subject.meshFollow-Up Studies
dc.subject.meshHeart Ventricles
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPostoperative Period
dc.subject.meshProspective Studies
dc.subject.meshSeverity of Illness Index
dc.subject.meshTime Factors
dc.subject.meshTranscatheter Aortic Valve Replacement
dc.subject.meshTreatment Outcome
dc.subject.meshVentricular Function, Left
dc.titleImmediate improvement of left ventricular mechanics following transcatheter aortic valve replacement.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number25
dspace.entity.typePublication

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