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A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial

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dc.contributor.authorRodríguez-Rubio, Miguel
dc.contributor.authorFigueira, Juan Carlos
dc.contributor.authorAcuña-Castroviejo, Darío
dc.contributor.authorBorobia, Alberto M.
dc.contributor.authorEscames, Germaine
dc.contributor.authorde la Oliva, Pedro
dc.contributor.authoraffiliation[Rodríguez-Rubio,M; de la Oliva,P] Pediatric Intensive Care Department, Hospital Universitario La Paz, Madrid, Spain. [Rodríguez-Rubio,M; de la Oliva,P] Department of Pediatrics, School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain. [Figueira,JC] Intensive Care Medicine Department, Hospital Universitario La Paz, Madrid, Spain. [Acuña-Castroviejo,D; Escames,G] Department of Physiology, Faculty of Medicine, Biomedical Research Center, Health Science Technology Park, University of Granada, Granada, Spain. [Acuña-Castroviejo,D; Escames,G] CIBERfes, Ibs Granada, Granada, Spain. [Acuña-Castroviejo,D] Clinical Laboratories, San Cecilio University Hospital, Granada, Spain. [Borobia,AM] Clinical Pharmacology Department, Clinical Trial Unit, Hospital Universitario La Paz – IdiPAZ, Madrid, Spain. [Borobia,AM] School of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.
dc.contributor.funderThe start-up Pharmamel LTD financed the trial.
dc.date.accessioned2021-06-25T11:27:24Z
dc.date.available2021-06-25T11:27:24Z
dc.date.issued2020-08-05
dc.description.versionYeses_ES
dc.identifier.citationRodríguez-Rubio M, Figueira JC, Acuña-Castroviejo D, Borobia AM, Escames G, de la Oliva P. A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial. Trials. 2020 Aug 5;21(1):699.es_ES
dc.identifier.doi10.1186/s13063-020-04632-4es_ES
dc.identifier.essn1745-6215
dc.identifier.pmcPMC7403786
dc.identifier.pmid32758298es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3393
dc.journal.titleTrials
dc.language.isoen
dc.page.number3 p.
dc.publisherBioMed Centrales_ES
dc.relation.publisherversionhttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-020-04632-4es_ES
dc.rights.accessRightsopen access
dc.subjectCOVID-19es_ES
dc.subjectRandomized controlled triales_ES
dc.subjectProtocoles_ES
dc.subjectMelatonines_ES
dc.subjectTreatmentes_ES
dc.subjectIntensive carees_ES
dc.subjectARDSes_ES
dc.subjectInflammationes_ES
dc.subjectInfecciones por coronaviruses_ES
dc.subjectEnsayo clínico controlado aleatorioes_ES
dc.subjectProtocolo de ensayo clínicoes_ES
dc.subjectMelatoninaes_ES
dc.subjectTerapéuticaes_ES
dc.subjectUnidades de cuidados intensivoses_ES
dc.subjectSíndrome de dificultad respiratoria del adultoes_ES
dc.subjectInflamaciónes_ES
dc.subject.meshMedical Subject Headings::Diseases::Respiratory Tract Diseases::Respiration Disorders::Respiratory Distress Syndrome, Adultes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Intravenouses_ES
dc.subject.meshMedical Subject Headings::Diseases::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infectionses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Double-Blind Methodes_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Health Care::Health Care Facilities, Manpower, and Services::Health Facilities::Hospital Units::Intensive Care Unitses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Length of Stayes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Melatonines_ES
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Disease Outbreaks::Epidemics::Pandemicses_ES
dc.subject.meshMedical Subject Headings::Diseases::Virus Diseases::Pneumonia, Virales_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topices_ES
dc.titleA phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled triales_ES
dc.typeletter
dc.type.hasVersionVoR
dspace.entity.typePublication

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