Publication: Prognosis of unexpected positive intraoperative cultures in arthroplasty revision: A large multicenter cohort
dc.contributor.author | Mancheño-Losa, Mikel | |
dc.contributor.author | Lora-Tamayo, Jaime | |
dc.contributor.author | Fernandez-Sampedro, Marta | |
dc.contributor.author | Rodriguez-Pardo, Dolors | |
dc.contributor.author | Muñoz-Mahamud, Ernesto | |
dc.contributor.author | Soldevila, Laura | |
dc.contributor.author | Palou, Mariona | |
dc.contributor.author | Barbero, Jose Maria | |
dc.contributor.author | Del-Toro, Maria Dolores | |
dc.contributor.author | Iribarren, Jose Antonio | |
dc.contributor.author | Benito, Natividad | |
dc.contributor.author | Sobrino, Beatriz | |
dc.contributor.author | Rico-Nieto, Alicia | |
dc.contributor.author | Guio-Carrion, Laura | |
dc.contributor.author | Gomez, Lucia | |
dc.contributor.author | Escudero-Sanchez, Rosa | |
dc.contributor.author | Garcia-Pais, Maria Jose | |
dc.contributor.author | Jover-Saenz, Alfredo | |
dc.contributor.author | Praena, Julia | |
dc.contributor.author | Baraia-Etxaburu, Josu Miren | |
dc.contributor.author | Auñon, Alvaro | |
dc.contributor.author | Muñez-Rubio, Elena | |
dc.contributor.author | Murillo, Oscar | |
dc.date.accessioned | 2023-05-03T15:05:03Z | |
dc.date.available | 2023-05-03T15:05:03Z | |
dc.date.issued | 2021-09-09 | |
dc.description.abstract | Background: The positive-intraoperative-cultures-type prosthetic joint infection (PIOC-PJI) is considered when surgical cultures yield microorganisms in presumed aseptic arthroplasty revisions. Herein we assess the risk factors for failure in the largest cohort of PIOC-PJI patients reported to date. Methods: A retrospective, observational, multicenter study was performed during 2007-2017. Surgeries leading to diagnose PIOC-PJI included only one-stage procedures with either complete or partial prosthesis revision. Failure was defined as recurrence caused by the same microorganism. Results: 203 cases were included (age 72 years, 52% females). Coagulase-negative staphylococci (n = 125, 62%) was the main etiology, but some episodes were caused by virulent bacteria (n = 51, 25%). Prosthesis complete and partial revision was performed in 93 (46%) and 110 (54%) cases, respectively. After a median of 3.4 years, failure occurred in 17 episodes (8.4%, 95%CI 5.3-13.1). Partial revision was an independent predictor of failure (HR 3.63; 95%CI 1.03-12.8), adjusted for gram-negative bacilli (GNB) infection (HR 2.68; 95%CI 0.91-7.89) and chronic renal impairment (HR 2.40; 95%CI 0.90-6.44). Treatment with biofilm-active antibiotics (rifampin/fluoroquinolones) had a favorable impact on infections caused by staphylococci and GNB. Conclusion: Overall prognosis of PIOC-PJI is good, but close follow-up is required in cases of partial revision and in infections caused by GNB. | |
dc.description.version | Si | |
dc.identifier.citation | Mancheño-Losa M, Lora-Tamayo J, Fernández-Sampedro M, Rodríguez-Pardo D, Muñoz-Mahamud E, Soldevila L, et al. Prognosis of unexpected positive intraoperative cultures in arthroplasty revision: A large multicenter cohort. J Infect. 2021 Nov;83(5):542-549 | |
dc.identifier.doi | 10.1016/j.jinf.2022.01.021 | |
dc.identifier.essn | 1532-2742 | |
dc.identifier.pmid | 35105460 | |
dc.identifier.unpaywallURL | http://www.journalofinfection.com/article/S0163445322000214/pdf | |
dc.identifier.uri | http://hdl.handle.net/10668/22320 | |
dc.issue.number | 5 | |
dc.journal.title | The Journal of infection | |
dc.journal.titleabbreviation | J Infect | |
dc.language.iso | en | |
dc.organization | Hospital Universitario Regional de Málaga | |
dc.page.number | 1 | |
dc.provenance | Realizada la curación de contenido 27/03/2025 | |
dc.publisher | Elsevier | |
dc.relation.publisherversion | https://linkinghub.elsevier.com/retrieve/pii/S0163-4453(21)00452-7 | |
dc.rights.accessRights | Restricted Access | |
dc.subject | Prosthetic joint infection | |
dc.subject | Infected arthroplasty | |
dc.subject | Biofilm | |
dc.subject | Foreign-boy infection | |
dc.subject | Arthritis | |
dc.subject.decs | Infecciones | |
dc.subject.decs | Prótesis e Implantes | |
dc.subject.decs | Biopelículas | |
dc.subject.decs | Artroplastia | |
dc.subject.decs | Articulaciones | |
dc.subject.decs | Antibacterianos | |
dc.subject.mesh | Bacteria | |
dc.subject.mesh | Arthroplasty | |
dc.subject.mesh | Prostheses and Implants | |
dc.subject.mesh | Biofilms | |
dc.subject.mesh | Fluoroquinolones | |
dc.subject.mesh | Anti-Bacterial Agents | |
dc.title | Prognosis of unexpected positive intraoperative cultures in arthroplasty revision: A large multicenter cohort | |
dc.type | research article | |
dc.type.hasVersion | VoR | |
dc.volume.number | 84 | |
dspace.entity.type | Publication |
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