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Implications of maraviroc and/or rapamycin in a mouse model of fragility.

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Date

2020-04-30

Authors

Pérez-Martínez, Laura
Romero, Lourdes
Muñoz-Galván, Sandra
Verdugo-Sivianes, Eva M
Rubio-Mediavilla, Susana
Oteo, José A
Carnero, Amancio
Blanco, José-Ramón

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Abstract

As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because patients with frailty demonstrate an overexpression of CCR5, rapamycin (RAPA) and/or maraviroc (MVC), two molecules able to decrease CCR5 expression, were evaluated. Muscle myostatin was reduced in all the therapeutic groups but the MVC group (p MVC and RAPA show a protective role in some factors involved in frailty. More studies are needed to prove their clinical applications. Eighty male homozygous IL10KOs were randomly assigned to one of 4 groups (n= 20): i) IL10KO group (IL10KO); ii) IL10KO receiving MVC in drinking water (MVC group), iii) IL10KO receiving RAPA in drinking water (RAPA group), and finally, iv) MVC-RAPA group that received MVC and RAPA in drinking water. Blood and muscle samples were analysed. Survival analysis, frailty index calculation, and functional assessment were also performed.

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MeSH Terms

Aging
Animals
Cytokines
Disease Models, Animal
Frailty
Interleukin-10
Male
Maraviroc
Mice
Mice, Knockout
Muscle, Skeletal
Random Allocation
Receptors, Chemokine
Sirolimus
Survival Rate

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Keywords

CCR5 antagonist, frailty, myostatin, rapamycin

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