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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.

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dc.contributor.authorBlokland, Gabriëlla A M
dc.contributor.authorGrove, Jakob
dc.contributor.authorChen, Chia-Yen
dc.contributor.authorCotsapas, Chris
dc.contributor.authorTobet, Stuart
dc.contributor.authorHanda, Robert
dc.contributor.authorSchizophrenia Working Group of the Psychiatric Genomics Consortium
dc.contributor.authorSt Clair, David
dc.contributor.authorLencz, Todd
dc.contributor.authorMowry, Bryan J
dc.contributor.authorPeriyasamy, Sathish
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorFullerton, Janice M
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorMitchell, Philip B
dc.contributor.authorSchofield, Peter R
dc.contributor.authorForstner, Andreas J
dc.contributor.authorDegenhardt, Franziska
dc.contributor.authorSchaupp, Sabrina
dc.contributor.authorComes, Ashley L
dc.contributor.authorKogevinas, Manolis
dc.contributor.authorScott, Laura J
dc.contributor.authorGuzman-Parra, José
dc.contributor.authorReif, Andreas
dc.contributor.authorStreit, Fabian
dc.contributor.authorŚwiątkowska, Beata
dc.contributor.authorSirignano, Lea
dc.contributor.authorCichon, Sven
dc.contributor.authorGrigoroiu-Serbanescu, Maria
dc.contributor.authorHauser, Joanna
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorSchulze, Thomas G
dc.contributor.authorStahl, Eli A
dc.contributor.authorNöthen, Markus M
dc.contributor.authorRietschel, Marcella
dc.contributor.authorKelsoe, John
dc.contributor.authorLeboyer, Marion
dc.contributor.authorJamain, Stéphane
dc.contributor.authorEtain, Bruno
dc.contributor.authorKnowles, James A
dc.contributor.authorBellivier, Frank
dc.contributor.authorVincent, John B
dc.contributor.authorAlda, Martin
dc.contributor.authorPerlis, Roy H
dc.contributor.authorO'Donovan, Claire
dc.contributor.authorCervantes, Pablo
dc.contributor.authorBiernacka, Joanna M
dc.contributor.authorFrye, Mark
dc.contributor.authorMcElroy, Susan L
dc.contributor.authorLandén, Mikael
dc.contributor.authorHamshere, Marian L
dc.contributor.authorSmeland, Olav B
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorVaaler, Arne E
dc.contributor.authorAndreassen, Ole A
dc.contributor.authorMajor Depressive Disorder Working Group of the Psychiatric Genomics Consortium
dc.contributor.authorMullins, Niamh
dc.contributor.authorBaune, Bernhard T
dc.contributor.authorAir, Tracy
dc.contributor.authorPreisig, Martin
dc.contributor.authorLucae, Susanne
dc.contributor.authorUher, Rudolf
dc.contributor.authorLevinson, Douglas F
dc.contributor.authorWeissman, Myrna M
dc.contributor.authorPotash, James B
dc.contributor.authorShi, Jianxin
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorAdams, Mark J
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorde Geus, Eco J C
dc.contributor.authorWillemsen, Gonneke
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorTiemeier, Henning
dc.contributor.authorCairns, Murray J
dc.contributor.authorGrabe, Hans J
dc.contributor.authorTeumer, Alexander
dc.contributor.authorVan der Auwera, Sandra
dc.contributor.authorTooney, Paul A
dc.contributor.authorVölker, Uwe
dc.contributor.authorHamilton, Steven P
dc.contributor.authorMagnusson, Patrik K E
dc.contributor.authorViktorin, Alexander
dc.contributor.authorMehta, Divya
dc.contributor.authorBreen, Gerome
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorLewis, Cathryn M
dc.contributor.authorSex Differences Cross-Disorder Analysis Group of the Psychiatric Genomics Consortium
dc.contributor.authoriPSYCH
dc.contributor.authorHougaard, David M
dc.contributor.authorNordentoft, Merete
dc.contributor.authorSanders, Alan R
dc.contributor.authorMors, Ole
dc.contributor.authorMortensen, Preben B
dc.contributor.authorWerge, Thomas
dc.contributor.authorWu, Jing Qin
dc.contributor.authorAls, Thomas D
dc.contributor.authorBørglum, Anders D
dc.contributor.authorPetryshen, Tracey L
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorGoldstein, Jill M
dc.contributor.authorKelly, Brian
dc.contributor.authorBuxbaum, Joseph D
dc.contributor.authorKirov, George
dc.contributor.authorSullivan, Patrick F
dc.contributor.authorCorvin, Aiden
dc.contributor.authorRiley, Brien P
dc.contributor.authorEsko, Tõnu
dc.contributor.authorMilani, Lili
dc.contributor.authorJönsson, Erik G
dc.contributor.authorPalotie, Aarno
dc.contributor.authorEhrenreich, Hannelore
dc.contributor.authorBegemann, Martin
dc.contributor.authorRujescu, Dan
dc.contributor.authorSteixner-Kumar, Agnes
dc.contributor.authorSham, Pak C
dc.contributor.authorIwata, Nakao
dc.contributor.authorWeinberger, Daniel R
dc.contributor.authorGejman, Pablo V
dc.contributor.authorGiegling, Ina
dc.contributor.authorKonte, Bettina
dc.contributor.authorHartmann, Annette M
dc.contributor.authorBramon, Elvira
dc.contributor.authorMurray, Robin M
dc.contributor.authorPato, Michele T
dc.contributor.authorLee, Jimmy
dc.contributor.authorMayoral, Fermin
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMolden, Espen
dc.contributor.authorOphoff, Roel A
dc.contributor.authorMcQuillin, Andrew
dc.contributor.authorBass, Nicholas J
dc.contributor.authorAdolfsson, Rolf
dc.contributor.authorMalhotra, Anil K
dc.contributor.authorBipolar Disorder Working Group of the Psychiatric Genomics Consortium
dc.date.accessioned2023-05-03T14:48:12Z
dc.date.available2023-05-03T14:48:12Z
dc.date.issued2021-03-23
dc.description.abstractSex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Across disorders, genome-wide significant single nucleotide polymorphism-by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10-8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels.
dc.identifier.citationBlokland, G. A. M., Grove, J., Chen, C. Y., Cotsapas, C., Tobet, S., Handa, R., et al. (2022). Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders. Biological psychiatry, 91(1), 102–117.
dc.identifier.doi10.1016/j.biopsych.2021.02.972
dc.identifier.essn1873-2402
dc.identifier.pmcPMC8458480
dc.identifier.pmid34099189
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8458480/pdf
dc.identifier.unpaywallURLhttps://discovery.dundee.ac.uk/files/84284933/Blokland_et_al...Goldstein_PreProof_032321.pdf
dc.identifier.urihttp://hdl.handle.net/10668/22054
dc.issue.number1
dc.journal.titleBiological psychiatry
dc.journal.titleabbreviationBiol Psychiatry
dc.language.isoen
dc.organizationHospital Universitario Regional de Málaga
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number102-117
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectBipolar disorder
dc.subjectGenome-wide association study
dc.subjectGenotype-by-sex interaction
dc.subjectMajor depressive disorder
dc.subjectSchizophrenia
dc.subjectSex differences
dc.subject.meshBipolar Disorder
dc.subject.meshDepressive Disorder, Major
dc.subject.meshEndothelial Cells
dc.subject.meshFemale
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshPsychotic Disorders
dc.subject.meshReceptors, Vascular Endothelial Growth Factor
dc.subject.meshSchizophrenia
dc.subject.meshSex Characteristics
dc.subject.meshSulfurtransferases
dc.titleSex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number91
dspace.entity.typePublication

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