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Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.

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dc.contributor.authorPalacín, Arantxa
dc.contributor.authorGómez-Casado, Cristina
dc.contributor.authorRivas, Luis A
dc.contributor.authorAguirre, Jacobo
dc.contributor.authorTordesillas, Leticia
dc.contributor.authorBartra, Joan
dc.contributor.authorBlanco, Carlos
dc.contributor.authorCarrillo, Teresa
dc.contributor.authorCuesta-Herranz, Javier
dc.contributor.authorFrutos, Consolación de
dc.contributor.authorGarcía Alvarez-Eire, Genoveva
dc.contributor.authorFernández, Francisco J
dc.contributor.authorGamboa, Pedro
dc.contributor.authorMuñoz, Rosa
dc.contributor.authorSánchez-Monge, Rosa
dc.contributor.authorSirvent, Sofía
dc.contributor.authorTorres, María J
dc.contributor.authorVarela-Losada, Susana
dc.contributor.authorRodríguez, Rosalía
dc.contributor.authorParro, Victor
dc.contributor.authorBlanca, Miguel
dc.contributor.authorSalcedo, Gabriel
dc.contributor.authorDíaz-Perales, Araceli
dc.contributor.authoraffiliation[Palacín,A; Gómez-Casado,C; Tordesillas,L; Sánchez-Monge,R; Díaz-Perales,A] Centro de Biotecnología y Genómica de Plantas (UPM-INIA), Pozuelo de Alarcón, Madrid, Spain. [Rivas,LA; Aguirre,J; Parro,V] Departamento de Evolución Molecular, Centro de Astrobiología (INTA-CSIC), Torrejón de Ardoz, Madrid, Spain. [Bartra,J; Muñoz,R] Unitat d’Alèrgia Servei Pneumologia i Alèrgia Respiratòria Universitat de Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigaciones Biomédicas en Red de Enfermedades Respiratorias (CIBERES), Barcelona, Spain. [Blanco,C; Frutos,C de] Servicio de Alergia, Hospital Universitario de la Princesa, Instituto de Investigación Sanitaria Princesa (IP), Madrid, Spain. [Carrillo,T] Servicio de Alergología, Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain. [Cuesta-Herranz,J] Unidad Servicio de Alergia, Fundación Jiménez Díaz, Madrid, Spain. [Fernández,FJ] Allergy Section, General University Hospital, Miguel Hernández University, Elche, Spain. [García Álvarez-Eire,G; Varela-Losada,S] Unidad de Alergología, Complexo Hospitalario, Ourense, Spain. [Torres,MJ; Blanca,M] Research Laboratory, Fundación IMABIS-Carlos Haya Hospital; Hospital Civil, Málaga, Spain. [Gamboa,P] Servicio de Alergia, Hospital de Basurto, Bilbao, Spain. [Sirvent,S; Rodríguez,R] Departamento de Bioquímica y Biología Molecular I, Facultad de Químicas, Universidad Complutense, Madrid, Spain. [Salcedo,G] Departamento de Biotecnología, ETSI Agrónomos, Universidad Politécnica, Madrid, Spain.es
dc.contributor.funderMinisterio de Ciencia e Innovación (projects BIO2009-07050 and SAF2008-04053) and FIS-Thematic Networks, and Co-operative Research Centers: RIRAAF (RD07/0064). C Gómez Casado and L Tordesillas have been supported by training grants from the Spanish Government (FPI and FPU programmes, MEC, respectively). J Aguirre has been supported by the Ministerio de Ciencia e Innovación (project FIS2011-27569) and Comunidad de Madrid, R&D Program of Activities, grant MODELICO-CM S2009ESP-1691.
dc.date.accessioned2013-07-10T11:38:39Z
dc.date.available2013-07-10T11:38:39Z
dc.date.issued2012-12-14
dc.description.abstractThe study of cross-reactivity in allergy is key to both understanding. the allergic response of many patients and providing them with a rational treatment In the present study, protein microarrays and a co-sensitization graph approach were used in conjunction with an allergen microarray immunoassay. This enabled us to include a wide number of proteins and a large number of patients, and to study sensitization profiles among members of the LTP family. Fourteen LTPs from the most frequent plant food-induced allergies in the geographical area studied were printed into a microarray specifically designed for this research. 212 patients with fruit allergy and 117 food-tolerant pollen allergic subjects were recruited from seven regions of Spain with different pollen profiles, and their sera were tested with allergen microarray. This approach has proven itself to be a good tool to study cross-reactivity between members of LTP family, and could become a useful strategy to analyze other families of allergens.es
dc.description.versionYeses
dc.identifier.citationPalacín A, Gómez-Casado C, Rivas LA, Aguirre J, Tordesillas L, Bartra J, et al. Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. PLoS ONE. 2012; 7(12):e50799es
dc.identifier.doi10.1371/journal.pone.0050799
dc.identifier.essn1932-6203
dc.identifier.pmcPMC3522694
dc.identifier.pmid23272072
dc.identifier.urihttp://hdl.handle.net/10668/1212
dc.journal.titlePloS one
dc.language.isoen
dc.publisherPublic Library of Sciencees
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0050799es
dc.rights.accessRightsopen access
dc.subjectReacciones Cruzadases
dc.subjectEstudios multicéntricos como asuntoes
dc.subjectHipersensibilidades
dc.subjectAnálisis de micromatriceses
dc.subjectInmunoanálisises
dc.subjectEspañaes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Immune System Phenomena::Immune System Processes::Antigen-Antibody Reactions::Cross Reactionses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteinses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Plant Proteinses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Plantes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Multicenter Studies as Topices
dc.subject.meshMedical Subject Headings::Diseases::Immune System Diseases::Hypersensitivityes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Microchip Analytical Procedures::Microarray Analysises
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immunologic Techniques::Immunoassayes
dc.subject.meshMedical Subject Headings::Anatomy::Plant Structures::Plant Components, Aerial::Fruites
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Plantses
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europe::Spaines
dc.subject.meshMedical Subject Headings::Anatomy::Plant Structures::Plant Components, Aerial::Flowering Tops::Flowers::Germ Cells, Plant::Pollenes
dc.titleGraph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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