Publication:
SEOM clinical guidelines for pancreatic and biliary tract cancer (2020).

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Date

2021-02-10

Authors

Gomez-España, Mª A
Montes, A F
Garcia-Carbonero, R
Mercade, T M
Maurel, J
Martin, A M
Pazo-Cid, R
Vera, R
Carrato, A
Feliu, J

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Springer
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Abstract

Pancreatic cancer (PC) and biliary tract cancer (BTC) are both aggressive and highly fatal malignancies. Nowadays we have a profound knowledge about the molecular landscape of these neoplasms and this has allowed new therapeutic options. Surgery is the only potentially curative therapy in both cancers, but disease recurrence is frequent. In PC, adjuvant treatment with mFOLFIRINOX has improved overall survival (OS) and in BTC adjuvant treatment with capecitabine seems to improve OS and relapse-free survival. Concomitant radio-chemotherapy could also be considered following R1 surgery in both neoplasms. Neoadjuvant treatment represents the best option for achieving an R0 resection in borderline PC. Upfront systemic chemotherapy is the treatment of choice in unresectable locally advanced PC and BTC; then locoregional therapy could be considered after an initial period of at least 3-4 months of systemic chemotherapy. In metastatic PC, FOLFIRINOX or Gemcitabine plus nab-paclitaxel have improved OS compared with gemcitabine alone. In metastatic BTC, cisplatin plus gemcitabine constitute the standard treatment. Progress in the knowledge of molecular biology has enabled the identification of new targets for therapy with encouraging results that could in the future improve the survival and quality of life of patients with PC and BTC.

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MeSH Terms

Albumins
Antineoplastic combined chemotherapy protocols
Biliary tract neoplasms
Capecitabine
Chemoradiotherapy
Chemotherapy, adjuvant
Cisplatin
Fluorouracil
Humans
Irinotecan
Leucovorin
Medical oncology
Neoadjuvant therapy
Neoplasm staging
Oxaliplatin
Paclitaxel
Palliative care
Pancreatic neoplasms
Quality of life
Societies, medical
Spain

DeCS Terms

Albúminas
Calidad de vida
Capecitabina
Cisplatino
Cuidados paliativos
España
Estadificación de neoplasias
Neoplasias pancreáticas

CIE Terms

Keywords

Biliary tract cancer, Chemotherapy, Pancreatic cancer, Radiotherapy, Treatment

Citation

Gómez-España MA, Montes AF, Garcia-Carbonero R, Mercadé TM, Maurel J, Martín AM, et al. SEOM clinical guidelines for pancreatic and biliary tract cancer (2020). Clin Transl Oncol. 2021 May;23(5):988-1000