Publication:
Oropharyngeal Colostrum Positively Modulates the Inflammatory Response in Preterm Neonates.

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Date

2020-02-05

Authors

Martin-Alvarez, Estefania
Diaz-Castro, Javier
Peña-Caballero, Manuela
Serrano-Lopez, Laura
Moreno-Fernandez, Jorge
Sanchez-Martinez, Belen
Martin-Peregrina, Francisca
Alonso-Moya, Mercedes
Maldonado-Lozano, Jose
Hurtado-Suazo, Jose A

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MDPI AG
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Abstract

During the first days of life , premature infants have physiological difficulties swallowing , thereby missing out on the benefits of breastfeeding . The aim of this study is to assess the effects of oropharyngeal mother ’s milk administration in the inflammatory signaling of extremely premature infants . Neonates (n = 100) (<32 week’s gestation and/or <1500 g) were divided into two groups: mother ’s milk group (n = 48), receiving 0.2 mL of oropharyngeal mother ’s milk every 4 h for the first 15 days of life , and a control group (n = 52), not receiving oropharyngeal mother ’s milk . Serum concentrations of interleukin (IL) IL-6 , IL-8 , IL-10 , IL-1ra , tumor necrosis factor alpha (TNF-α), and interferón gamma (IFN-γ) were assessed at 1, 3, 15, and 30 days of postnatal life . Maternal and neonatal outcomes were collected. The rate of common neonatal morbidities in both groups was similar. The mother ’s milk group achieved full enteral feeding earlier, and showed a decrease in Il-6 on days 15 and 30, in IL-8 on day 30, and in TNF-α and INF-γ on day 15, as well as an increase in IL-1ra on days 3 and 15 and in IL-10 on day 30. Oropharyngeal mother ’s milk administration for 15 days decreases the pro-inflammatory state of preterm neonates and provides full enteral nutrition earlier, which could have a positive influence on the development of the immune system and inflammatory response, thereby positively influencing other developmental outcomes.

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MeSH Terms

Biomarkers
Colostrum
Cytokines
Enteral Nutrition
Female
Humans
Infant, Extremely Premature
Infant, Newborn
Infant, Premature, Diseases
Inflammation
Milk, Human
Pregnancy
Treatment Outcome

DeCS Terms

Proteína antagonista del receptor de interleucina 1
Nutrición enteral
Deglución
Interleucinas
Lactancia materna
Suero
Sistema inmunológico
Factor de necrosis tumoral alfa

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Keywords

clinical outcomes, colostrum administration, inflammation, premature neonates

Citation

Martín-Álvarez E, Diaz-Castro J, Peña-Caballero M, Serrano-López L, Moreno-Fernández J, Sánchez-Martínez B, et al. Oropharyngeal Colostrum Positively Modulates the Inflammatory Response in Preterm Neonates. Nutrients. 2020 Feb 5;12(2):413.