Publication: Clinical Trials of Thermosensitive Nanomaterials: An Overview.
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Identifiers
Date
2019-01-30
Authors
Nardecchia, Stefania
Sanchez-Moreno, Paola
Vicente, Juan de
Marchal, Juan A
Boulaiz, Houria
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI AG
Abstract
Currently, we are facing increasing demand to develop efficient systems for the detection and treatment of diseases that can realistically improve distinct aspects of healthcare in our society. Sensitive nanomaterials that respond to environmental stimuli can play an important role in this task. In this manuscript, we review the clinical trials carried out to date on thermosensitive nanomaterials, including all those clinical trials in hybrid nanomaterials that respond to other stimuli (e.g., magnetic, infrared radiation, and ultrasound). Specifically, we discuss their use in diagnosis and treatment of different diseases. At present, none of the existing trials focused on diagnosis take advantage of the thermosensitive characteristics of these nanoparticles. Indeed, almost all clinical trials consulted explore the use of Ferumoxytol as a current imaging test enhancer. However, the thermal property is being further exploited in the field of disease treatment, especially for the delivery of antitumor drugs. In this regard, ThermoDox®, based on lysolipid thermally sensitive liposome technology to encapsulate doxorubicin (DOX), is the flagship drug. In this review, we have evidenced the discrepancy existing between the number of published papers in thermosensitive nanomaterials and their clinical use, which could be due to the relative novelty of this area of research; more time is needed to validate it through clinical trials. We have no doubt that in the coming years there will be an explosion of clinical trials related to thermosensitive nanomaterials that will surely help to improve current treatments and, above all, will impact on patients' quality of life and life expectancy.
Description
MeSH Terms
Humans
Liposomes
Ferrosoferric Oxide
Quality of Life
Antineoplastic Agents
Doxorubicin
Antibiotics, Antineoplastic
Nanoparticles
Delivery of Health Care
Life Expectancy
Magnetic Phenomena
Liposomes
Ferrosoferric Oxide
Quality of Life
Antineoplastic Agents
Doxorubicin
Antibiotics, Antineoplastic
Nanoparticles
Delivery of Health Care
Life Expectancy
Magnetic Phenomena
DeCS Terms
Antibióticos antineoplásicos
Antineoplásicos
Atención a la salud
Calidad de vida
Doxorrubicina
Esperanza de vida
Fenómenos magnéticos
Humanos
Liposomas
Nanopartículas
Óxido Ferrosoférrico
Antineoplásicos
Atención a la salud
Calidad de vida
Doxorrubicina
Esperanza de vida
Fenómenos magnéticos
Humanos
Liposomas
Nanopartículas
Óxido Ferrosoférrico
CIE Terms
Keywords
Ferumoxytol, ThermoDox, USPIO, gold nanoparticles, magnetic nanoparticles, thermosensitive nanomaterials
Citation
Nardecchia S, Sánchez-Moreno P, Vicente J, Marchal JA, Boulaiz H. Clinical Trials of Thermosensitive Nanomaterials: An Overview. Nanomaterials (Basel). 2019 Feb 2;9(2):191