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Genetic variants associated with longitudinal changes in brain structure across the lifespan.

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dc.contributor.authorBrouwer, Rachel M
dc.contributor.authorKlein, Marieke
dc.contributor.authorGrasby, Katrina L
dc.contributor.authorSchnack, Hugo G
dc.contributor.authorJahanshad, Neda
dc.contributor.authorTeeuw, Jalmar
dc.contributor.authorThomopoulos, Sophia I
dc.contributor.authorSprooten, Emma
dc.contributor.authorFranz, Carol E
dc.contributor.authorGogtay, Nitin
dc.contributor.authorKremen, William S
dc.contributor.authorPanizzon, Matthew S
dc.contributor.authorOlde Loohuis, Loes M
dc.contributor.authorWhelan, Christopher D
dc.contributor.authorAghajani, Moji
dc.contributor.authorAlloza, Clara
dc.contributor.authorAlnæs, Dag
dc.contributor.authorArtiges, Eric
dc.contributor.authorAyesa-Arriola, Rosa
dc.contributor.authorBarker, Gareth J
dc.contributor.authorBastin, Mark E
dc.contributor.authorBlok, Elisabet
dc.contributor.authorBøen, Erlend
dc.contributor.authorBreukelaar, Isabella A
dc.contributor.authorBright, Joanna K
dc.contributor.authorBuimer, Elizabeth E L
dc.contributor.authorBülow, Robin
dc.contributor.authorCannon, Dara M
dc.contributor.authorCiufolini, Simone
dc.contributor.authorCrossley, Nicolas A
dc.contributor.authorDamatac, Christienne G
dc.contributor.authorDazzan, Paola
dc.contributor.authorde Mol, Casper L
dc.contributor.authorde Zwarte, Sonja M C
dc.contributor.authorDesrivières, Sylvane
dc.contributor.authorDíaz-Caneja, Covadonga M
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorDohm, Katharina
dc.contributor.authorFröhner, Juliane H
dc.contributor.authorGoltermann, Janik
dc.contributor.authorGrigis, Antoine
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorHan, Laura K M
dc.contributor.authorHarris, Mathew A
dc.contributor.authorHartman, Catharina A
dc.contributor.authorHeany, Sarah J
dc.contributor.authorHeindel, Walter
dc.contributor.authorHeslenfeld, Dirk J
dc.contributor.authorHohmann, Sarah
dc.contributor.authorIttermann, Bernd
dc.contributor.authorJansen, Philip R
dc.contributor.authorJanssen, Joost
dc.contributor.authorJia, Tianye
dc.contributor.authorJiang, Jiyang
dc.contributor.authorJockwitz, Christiane
dc.contributor.authorKarali, Temmuz
dc.contributor.authorKeeser, Daniel
dc.contributor.authorKoevoets, Martijn G J C
dc.contributor.authorLenroot, Rhoshel K
dc.contributor.authorMalchow, Berend
dc.contributor.authorMandl, René C W
dc.contributor.authorMedel, Vicente
dc.contributor.authorMeinert, Susanne
dc.contributor.authorMorgan, Catherine A
dc.contributor.authorMühleisen, Thomas W
dc.contributor.authorNabulsi, Leila
dc.contributor.authorOpel, Nils
dc.contributor.authorde la Foz, Víctor Ortiz-García
dc.contributor.authorOvers, Bronwyn J
dc.contributor.authorPaillère Martinot, Marie-Laure
dc.contributor.authorRedlich, Ronny
dc.contributor.authorMarques, Tiago Reis
dc.contributor.authorRepple, Jonathan
dc.contributor.authorRoberts, Gloria
dc.contributor.authorRoshchupkin, Gennady V
dc.contributor.authorSetiaman, Nikita
dc.contributor.authorShumskaya, Elena
dc.contributor.authorStein, Frederike
dc.contributor.authorSudre, Gustavo
dc.contributor.authorTakahashi, Shun
dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorTordesillas-Gutiérrez, Diana
dc.contributor.authorvan der Lugt, Aad
dc.contributor.authorvan Haren, Neeltje E M
dc.contributor.authorWardlaw, Joanna M
dc.contributor.authorWen, Wei
dc.contributor.authorWesteneng, Henk-Jan
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorZhu, Alyssa H
dc.contributor.authorZugman, Andre
dc.contributor.authorArmstrong, Nicola J
dc.contributor.authorBonfiglio, Gaia
dc.contributor.authorBralten, Janita
dc.contributor.authorDalvie, Shareefa
dc.contributor.authorDavies, Gail
dc.contributor.authorDi Forti, Marta
dc.contributor.authorDing, Linda
dc.contributor.authorDonohoe, Gary
dc.contributor.authorForstner, Andreas J
dc.contributor.authorGonzalez-Peñas, Javier
dc.contributor.authorGuimaraes, Joao P O F T
dc.contributor.authorHomuth, Georg
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorKnol, Maria J
dc.contributor.authorKwok, John B J
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorMather, Karen A
dc.contributor.authorMilaneschi, Yuri
dc.contributor.authorMorris, Derek W
dc.contributor.authorNöthen, Markus M
dc.contributor.authorPapiol, Sergi
dc.contributor.authorRietschel, Marcella
dc.contributor.authorSantoro, Marcos L
dc.contributor.authorSteen, Vidar M
dc.contributor.authorStein, Jason L
dc.contributor.authorStreit, Fabian
dc.contributor.authorTankard, Rick M
dc.contributor.authorTeumer, Alexander
dc.contributor.authorvan 't Ent, Dennis
dc.contributor.authorvan der Meer, Dennis
dc.contributor.authorvan Eijk, Kristel R
dc.contributor.authorVassos, Evangelos
dc.contributor.authorVázquez-Bourgon, Javier
dc.contributor.authorWitt, Stephanie H
dc.contributor.authorIMAGEN Consortium
dc.contributor.authorAdams, Hieab H H
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorAmes, David
dc.contributor.authorAmunts, Katrin
dc.contributor.authorAndreassen, Ole A
dc.contributor.authorArango, Celso
dc.contributor.authorBanaschewski, Tobias
dc.contributor.authorBaune, Bernhard T
dc.contributor.authorBelangero, Sintia I
dc.contributor.authorBokde, Arun L W
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorBressan, Rodrigo A
dc.contributor.authorBrodaty, Henry
dc.contributor.authorBuitelaar, Jan K
dc.contributor.authorCahn, Wiepke
dc.contributor.authorCaspers, Svenja
dc.contributor.authorCichon, Sven
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorCox, Simon R
dc.contributor.authorDannlowski, Udo
dc.contributor.authorElvsåshagen, Torbjørn
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorFalkai, Peter G
dc.contributor.authorFisher, Simon E
dc.contributor.authorFlor, Herta
dc.contributor.authorFullerton, Janice M
dc.contributor.authorGaravan, Hugh
dc.contributor.authorGowland, Penny A
dc.contributor.authorGrabe, Hans J
dc.contributor.authorHahn, Tim
dc.contributor.authorHeinz, Andreas
dc.contributor.authorHillegers, Manon
dc.contributor.authorHoare, Jacqueline
dc.contributor.authorHoekstra, Pieter J
dc.contributor.authorIkram, Mohammad A
dc.contributor.authorJackowski, Andrea P
dc.contributor.authorJansen, Andreas
dc.contributor.authorJönsson, Erik G
dc.contributor.authorKahn, Rene S
dc.contributor.authorKircher, Tilo
dc.contributor.authorKorgaonkar, Mayuresh S
dc.contributor.authorKrug, Axel
dc.contributor.authorLemaitre, Herve
dc.contributor.authorMalt, Ulrik F
dc.contributor.authorMartinot, Jean-Luc
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMitchell, Philip B
dc.contributor.authorMuetzel, Ryan L
dc.contributor.authorMurray, Robin M
dc.contributor.authorNees, Frauke
dc.contributor.authorNenadić, Igor
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorOphoff, Roel A
dc.contributor.authorPan, Pedro M
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorPoustka, Luise
dc.contributor.authorSachdev, Perminder S
dc.contributor.authorSalum, Giovanni A
dc.contributor.authorSchofield, Peter R
dc.contributor.authorSchumann, Gunter
dc.contributor.authorShaw, Philip
dc.contributor.authorSim, Kang
dc.contributor.authorSmolka, Michael N
dc.contributor.authorStein, Dan J
dc.contributor.authorTrollor, Julian N
dc.contributor.authorvan den Berg, Leonard H
dc.contributor.authorVeldink, Jan H
dc.contributor.authorWalter, Henrik
dc.contributor.authorWestlye, Lars T
dc.contributor.authorWhelan, Robert
dc.contributor.authorWhite, Tonya
dc.contributor.authorWright, Margaret J
dc.contributor.authorMedland, Sarah E
dc.contributor.authorFranke, Barbara
dc.contributor.authorThompson, Paul M
dc.contributor.authorHulshoff Pol, Hilleke E
dc.date.accessioned2023-05-03T13:26:36Z
dc.date.available2023-05-03T13:26:36Z
dc.date.issued2022-04-05
dc.description.abstractHuman brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures. The most robustly identified genes GPR139, DACH1 and APOE are associated with metabolic processes. We demonstrate global genetic overlap with depression, schizophrenia, cognitive functioning, insomnia, height, body mass index and smoking. Gene set findings implicate both early brain development and neurodegenerative processes in the rates of brain changes. Identifying variants involved in structural brain changes may help to determine biological pathways underlying optimal and dysfunctional brain development and aging.
dc.identifier.doi10.1038/s41593-022-01042-4
dc.identifier.essn1546-1726
dc.identifier.pmcPMC10040206
dc.identifier.pmid35383335
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10040206/pdf
dc.identifier.unpaywallURLhttps://pure.rug.nl/ws/files/213351503/s41593_022_01042_4.pdf
dc.identifier.urihttp://hdl.handle.net/10668/19576
dc.issue.number4
dc.journal.titleNature neuroscience
dc.journal.titleabbreviationNat Neurosci
dc.language.isoen
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.page.number421-432
dc.pubmedtypeJournal Article
dc.pubmedtypeMeta-Analysis
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeResearch Support, U.S. Gov't, Non-P.H.S.
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.rights.accessRightsopen access
dc.subject.meshAging
dc.subject.meshBrain
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshLongevity
dc.subject.meshMagnetic Resonance Imaging
dc.titleGenetic variants associated with longitudinal changes in brain structure across the lifespan.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number25
dspace.entity.typePublication

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