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Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice

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dc.contributor.authorLeyva-Jiménez, Francisco Javier
dc.contributor.authorRuiz-Malagón, Antonio Jesús
dc.contributor.authorMolina-Tijeras, José Alberto
dc.contributor.authorDiez-Echave, Patricia
dc.contributor.authorVezza, Teresa
dc.contributor.authorHidalgo-García, Laura
dc.contributor.authorLozano-Sánchez, Jesús
dc.contributor.authorArráez-Román, David
dc.contributor.authorCenis, José Luis
dc.contributor.authorLozano-Pérez, Antonio Abel
dc.contributor.authorRodríguez-Nogales, Alba
dc.contributor.authorSegura-Carretero, Antonio
dc.contributor.authorGálvez, Julio
dc.contributor.authoraffiliation[Leyva-Jiménez,FJ; Lozano-Sánchez,J; Arráez-Román,D; Segura-Carretero,A] Research and Development Functional Food Centre, Health Science Technological Park, Granada, Spain. [Ruiz-Malagón,AJ; Molina-Tijeras,JA; Diez-Echave,P; Vezza,T; Hidalgo-García,L; Rodríguez-Nogales,A; Gálvez,J] CIBER-EHD, Department of Pharmacology, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain. [Ruiz-Malagón,AJ; Molina-Tijeras,JA; Diez-Echave,P; Vezza,T; Hidalgo-García,L; Rodríguez-Nogales,A; Gálvez,J] Instituto de Investigación Biosanitaria de Granada (Ibs. GRANADA), Granada, Spain. [Lozano-Sánchez,J] Department of Nutrition and Food Science, Center for Biomedical Research (CIBM), University of Granada, Granada, Spain. [Arráez-Román,D; Segura-Carretero,A] Department of Analytical Chemistry, University of Granada, Granada, Spain. [Cenis,JL; Lozano-Pérez,AA] Departamento de Biotecnología, Genómica y Mejora Vegetal, Instituto Murciano de Investigación y Desarrollo Agrario y Alimentario, La Alberca (Murcia), Spain. [Rodríguez-Nogales,A] Servicio de Digestivo, Hospital Universitario Virgen de las Nieves, Granada, Spain.
dc.contributor.funderThis research was funded by the Junta de Andalucía (CTS 164) and by the Spanish Ministry of Economy and Competitiveness (AGL2015-67995-C3-3-R), with funds from the European Commission (FEDER/ERDF). Lozano-Pérez’s research contract is partially supported (80%) by the ERDF/FEDER Operational Programme of the Region of Murcia CCI Nº 2007ES161PO001 (Project No. 14-20/20). The CIBER-EHD is funded by the Instituto de Salud Carlos III. A.J. Ruiz-Malagón and L. Hidalgo-García are predoctoral fellows from University of Granada of “Programa de Doctorado: Medicina Clínica y Salud Pública” (Formación de Profesorado Universitario Program); J.A. Molina-Tijeras is a predoctoral fellow from University of Granada of “Programa de Doctorado: Nutrición y Ciencias de los Alimentos”. P. Diez-Echave is a predoctoral fellow from University of Granada of “Programa de Doctorado: Medicina Clínica y Salud Pública”, T. Vezza is a postdoctoral fellow from Instituto de Investigación Biosanitaria (Ibs.GRANADA) and A. Rodriguez-Nogales is postdoctoral fellow from Instituto de Salud Carlos III (Miguel Servet Program).
dc.date.accessioned2022-08-30T10:32:24Z
dc.date.available2022-08-30T10:32:24Z
dc.date.issued2020-08-11
dc.description.abstractIncreased levels of reactive oxygen species (ROS) and a low-grade chronic inflammation in multiple organs have been demonstrated in obesity. Morus alba leaves extracts (MAEs) have been used in traditional medicine as anti-inflammatory agents. In this work, the bioactive compounds of different genotypes of M. alba L. (Filipina, Valenciana Temprana, Kokuso, and Italia) were analyzed not only by reverse phase high performance liquid chromatography-electrospray ionization-time of flight-mass spectrometry (RP-HPLC-ESI-TOF-MS) and hydrophilic interaction chromatography-electrospray ionization-time of flight-mass spectrometry (HILIC-ESI-TOF-MS), but also screened for in vitro and in vivo antioxidant activity by means of DPPH· radical scavenging assay and Caenorhabditis elegans model. These MAEs were administered daily in a model of diet-induced obesity in mice. Filipina and Italia genotypes significantly reduced weight gain, the glycemic levels in high fat diet, as well as, levels of LDL-cholesterol and triglycerides. Filipina and Italia MAEs also reduced the expression of proinflammatory mediators such as Tnf-α, Il-1β, Il-6 and increased the levels of adiponectin and AMPK, which exert anti-inflammatory effects. Moreover, Italia genotype ameliorated the intestinal barrier function. In conclusion, Filipina and Italia methanolic extracts show the highest antioxidant and anti-inflammatory effect, due to the presence of compounds such as protocatechuic acid or quercetin-3-glucoside, and they could be developed as a complementary treatment for obesity and metabolic disorders.es_ES
dc.description.versionYeses_ES
dc.identifier.citationLeyva-Jiménez FJ, Ruiz-Malagón AJ, Molina-Tijeras JA, Diez-Echave P, Vezza T, Hidalgo-García L, et al. Comparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Mice. Antioxidants. 2020 Aug 11;9(8):733es_ES
dc.identifier.doi10.3390/antiox9080733es_ES
dc.identifier.essn2076-3921
dc.identifier.pmcPMC7465205
dc.identifier.pmid32796677es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3967
dc.journal.titleAntioxidants
dc.language.isoen
dc.page.number24 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/9/8/733/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMorus alba leaveses_ES
dc.subjectHigh fat dietes_ES
dc.subjectObesityes_ES
dc.subjectChemical characterizationes_ES
dc.subjectAnti-inflammatoryes_ES
dc.subjectMetabolic disorderses_ES
dc.subjectDieta alta en grasaes_ES
dc.subjectObesidades_ES
dc.subjectAntiinflamatorioses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Micees_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry::Spectrometry, Mass, Electrospray Ionizationes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Chromatography::Chromatography, Liquid::Chromatography, High Pressure Liquides_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Specialty Uses of Chemicals::Protective Agents::Antioxidantses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Oxygen Compounds::Reactive Oxygen Specieses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intracellular Signaling Peptides and Proteins::AMP-Activated Protein Kinaseses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Adiponectines_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Invertebrates::Helminths::Nematoda::Secernentea::Rhabditida::Rhabditoidea::Caenorhabditis::Caenorhabditis eleganses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Plants::Viridiplantae::Streptophyta::Embryophyta::Angiosperms::Moraceae::Moruses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Carbocyclic::Benzoates::Hydroxybenzoateses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, High-Fates_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Complex Mixtures::Biological Products::Plant Preparations::Plant Extractses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Physicochemical Phenomena::Hydrophobic and Hydrophilic Interactionses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agentses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Complementary Therapies::Medicine, Traditionales_ES
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseaseses_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Glycerides::Triglycerideses_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Body Weight Changes::Weight Gaines_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholesteroles_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotypees_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesityes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Plant Structures::Plant Components, Aerial::Plant Leaveses_ES
dc.titleComparative Study of the Antioxidant and Anti-Inflammatory Effects of Leaf Extracts from Four Different Morus alba Genotypes in High Fat Diet-Induced Obesity in Micees_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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