The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control

Manzano-López, Javier; Monje-Casas, Fernando

Publication:
The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control

dc.contributor.author	Manzano-López, Javier
dc.contributor.author	Monje-Casas, Fernando
dc.contributor.authoraffiliation	[Manzano-López,J; Monje-Casas,F] Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER), Spanish National Research Council (CSIC)—University of Seville—University Pablo de Olavide, Sevilla, Spain.
dc.contributor.funder	This research was funded by the European Union (FEDER) and the Spanish Ministry of Economy, Industry and Competitiveness (BFU2016-76642-P grant and IJCI-2017-33087 Juan de la Cierva research contract to Javier Manzano). All authors have read and agreed to the published version of the manuscript.
dc.date.accessioned	2022-06-27T07:14:38Z
dc.date.available	2022-06-27T07:14:38Z
dc.date.issued	2020-01-21
dc.description.abstract	The Cdc14 phosphatase is a key regulator of mitosis in the budding yeast Saccharomyces cerevisiae. Cdc14 was initially described as playing an essential role in the control of cell cycle progression by promoting mitotic exit on the basis of its capacity to counteract the activity of the cyclin-dependent kinase Cdc28/Cdk1. A compiling body of evidence, however, has later demonstrated that this phosphatase plays other multiple roles in the regulation of mitosis at different cell cycle stages. Here, we summarize our current knowledge about the pivotal role of Cdc14 in cell cycle control, with a special focus in the most recently uncovered functions of the phosphatase.	es_ES
dc.description.version	Yes	es_ES
dc.identifier.citation	Manzano-López J, Monje-Casas F. The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control. Int J Mol Sci. 2020 Jan 21;21(3):709	es_ES
dc.identifier.doi	10.3390/ijms21030709	es_ES
dc.identifier.essn	1422-0067
dc.identifier.pmc	PMC7038166
dc.identifier.pmid	31973188	es_ES
dc.identifier.uri	http://hdl.handle.net/10668/3704
dc.journal.title	International Journal of Molecular Sciences
dc.language.iso	en
dc.page.number	15 p.
dc.publisher	MDPI	es_ES
dc.relation.publisherversion	https://www.mdpi.com/1422-0067/21/3/709/htm	es_ES
dc.rights	Atribución 4.0 Internacional	*
dc.rights.accessRights	Acceso abierto	es_ES
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Cdc14	es_ES
dc.subject	Phosphatase	es_ES
dc.subject	Mitotic exit	es_ES
dc.subject	Genome stability	es_ES
dc.subject	Nucleolus	es_ES
dc.subject	Autophagy	es_ES
dc.subject	Cytokinesis	es_ES
dc.subject	Proteína quinasa CDC2	es_ES
dc.subject	Monoéster fosfórico hidrolasas	es_ES
dc.subject	Inestabilidad genómica	es_ES
dc.subject	Nucléolo celular	es_ES
dc.subject	Autofagia	es_ES
dc.subject	Citocinesis	es_ES
dc.subject	Puntos de control del ciclo celular	es_ES
dc.subject	Replicación del ADN	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Autophagy	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cell Cycle Proteins::Cyclin-Dependent Kinases::CDC2-CDC28 Kinases::CDC2 Protein Kinase	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cell Cycle Proteins::Cyclin-Dependent Kinases::CDC2-CDC28 Kinases::CDC28 Protein Kinase, S cerevisiae	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Cycle Checkpoints	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cell Cycle Proteins	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cell Cycle Proteins::Cyclin-Dependent Kinases	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Cytokinesis	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::DNA Replication	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNA::DNA, Ribosomal	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Gene Expression Regulation, Fungal	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genomic Instability	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Cycle::Cell Division::Cell Nucleus Division::Mitosis	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Protein Tyrosine Phosphatases	es_ES
dc.subject.mesh	Medical Subject Headings::Organisms::Eukaryota::Fungi::Ascomycota::Saccharomycetales::Saccharomyces::Saccharomyces cerevisiae	es_ES
dc.subject.mesh	Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Fungal Proteins::Saccharomyces cerevisiae Proteins	es_ES
dc.subject.mesh	Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression::Transcription, Genetic	es_ES
dc.title	The Multiple Roles of the Cdc14 Phosphatase in Cell Cycle Control	es_ES
dc.type	review article
dc.type.hasVersion	VoR
dspace.entity.type	Publication