Publication:
Gastrointestinal stromal tumors (GISTs): SEAP-SEOM consensus on pathologic and molecular diagnosis.

dc.contributor.authorMartin-Broto, J
dc.contributor.authorMartinez-Marin, V
dc.contributor.authorSerrano, C
dc.contributor.authorHindi, N
dc.contributor.authorLopez-Guerrero, J A
dc.contributor.authorBiscuola, M
dc.contributor.authorRamos-Asensio, R
dc.contributor.authorVallejo-Benitez, A
dc.contributor.authorMarcilla-Plaza, D
dc.contributor.authorGonzalez-Campora, R
dc.date.accessioned2023-01-25T09:43:14Z
dc.date.available2023-01-25T09:43:14Z
dc.date.issued2017-05
dc.description.abstractGastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the digestive tract , with an incidence of 1.1 cases/100,000 inhabitants/year. A group of experts from the Spanish Society of Pathology and the Spanish Society of Oncology met to discuss a brief update on GISTs and agree on aspects relating to the pathological and molecular diagnosis of these tumors . GISTs are generally solitary, well-circumscribed lesions of variable size (<10 mm–35 cm) that may present with intra- or extra- luminal parietal growth or a mixed-type (hourglass) growth pattern. Histologically, they are unencapsulated neoplasms displaying expansive growth and spindle-shaped (70%), epithelioid (20%), or mixed cellularity (10%). Mitotic activity is generally moderate or low and should be evaluated only in areas with high cellularity or higher mitotic frequency. The great majority of GISTs harbour mutually exclusive activating mutations in genes coding for the type III receptor tyrosine kinases KIT and PDGFRA; less commonly, GISTs have also been reported to display mutations elsewhere, including BRAF and NF1 and SDH-complex genes . The method most widely used to detect KIT and PDGFRA mutations is amplification of the exons involved by polymerase chain reaction followed by direct sequencing (Sanger method ) of these amplification products. Molecular analyses should always specify the type of analysis performed, the region or mutations evaluated, and the sensitivity of the detection method employed.
dc.description.versionSi
dc.identifier.citationMartin-Broto J, Martinez-Marín V, Serrano C, Hindi N, López-Guerrero JA, Bisculoa M, et al. Gastrointestinal stromal tumors (GISTs): SEAP-SEOM consensus on pathologic and molecular diagnosis. Clin Transl Oncol. 2017 May;19(5):536-545.
dc.identifier.doi10.1007/s12094-016-1581-2
dc.identifier.essn1699-3055
dc.identifier.pmid27943096
dc.identifier.unpaywallURLhttps://link.springer.com/content/pdf/10.1007%2Fs12094-017-1619-0.pdf
dc.identifier.urihttp://hdl.handle.net/10668/10823
dc.issue.number5
dc.journal.titleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
dc.journal.titleabbreviationClin Transl Oncol
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationHospital Universitario Virgen Macarena
dc.page.number536-545
dc.provenanceRealizada la curación de contenido 27/06/2025.
dc.publisherSpringer Milano
dc.pubmedtypeJournal Article
dc.relation.publisherversionhttps://dx.doi.org/10.1007/s12094-016-1581-2
dc.rights.accessRightsRestricted Access
dc.subjectGastrointestinal stromal tumor
dc.subjectPathologic diagnosis
dc.subjectMolecular diagnosis
dc.subjectGIST
dc.subjectConsensus
dc.subject.decsMutación
dc.subject.decsNeoplasias
dc.subject.decsDiagnóstico
dc.subject.decsTirosina
dc.subject.decsFosfotransferasas
dc.subject.decsFenobarbital
dc.subject.meshGastrointestinal Stromal Tumors
dc.subject.meshProto-Oncogene Proteins B-raf
dc.subject.meshIncidence
dc.subject.meshMutation
dc.subject.meshExons
dc.subject.meshReceptor Protein-Tyrosine Kinases
dc.subject.meshTyrosine
dc.titleGastrointestinal stromal tumors (GISTs): SEAP-SEOM consensus on pathologic and molecular diagnosis.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number19
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
RISalud_Accesorestringido.pdf
Size:
93.39 KB
Format:
Adobe Portable Document Format