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Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect

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dc.contributor.authorRodríguez-Pérez, María Dolores
dc.contributor.authorLópez-Villodres, Juan Antonio
dc.contributor.authorArrebola, María Monsalud
dc.contributor.authorMartín-Aurioles, Esther
dc.contributor.authorFernández-Prior, África
dc.contributor.authorBermúdez-Oria, Alejandra
dc.contributor.authorRíos, María Carmen
dc.contributor.authorDe La Cruz, José Pedro
dc.contributor.authorGonzález-Correa, José Antonio
dc.contributor.authoraffiliation[Rodríguez-Pérez,MD; De La Cruz,JP; González-Correa,JA] Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute (IBIMA), University of Malaga, Málaga, Spain. [López-Villodres,JA; Ríos,MC] Area of Human Histology, Faculty of Medicine, University of Malaga, Málaga, Spain. [Arrebola,MM] Clinical Laboratory, Clinical Management Unit, Hospital Axarquía, AGSEMA, Málaga, Spain. [Martín-Aurioles,E] Clinical Management Unit La Roca, Distrito Sanitario, AGSEMA, Málaga, Spain. [Fernández-Prior,A; Bermúdez-Oria,A] Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Seville, Spain.
dc.contributor.funderThis study was supported in part by the Consejería de Salud. Junta de Andalucía (Spain), Proyectos de Investigación en Salud (Regional Ministry of Health. Junta de Andalucía (Spain), Health Research Projects) (PI-0129-2017) and by Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness) (Spain), Centro para el Desarrollo Tecnológico Industrial (Center for the Development of Industrial Technology), FEDER Interconecta Pluri-Regional Program (Spain), (PS17173. NUTRADAF, ITC-20161265).
dc.date.accessioned2022-11-07T10:23:59Z
dc.date.available2022-11-07T10:23:59Z
dc.date.issued2021-11-08
dc.description.abstractThe aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.es_ES
dc.description.versionYeses_ES
dc.identifier.citationRodríguez-Pérez MD, López-Villodres JA, Arrebola MM, Martín-Aurioles E, Fernández-Prior Á, Bermúdez-Oria A, et al. Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect. Antioxidants. 2021 Nov 8;10(11):1783es_ES
dc.identifier.doi10.3390/antiox10111783es_ES
dc.identifier.essn2076-3921
dc.identifier.pmcPMC8615082
dc.identifier.pmid34829654es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4338
dc.journal.titleAntioxidants
dc.language.isoen
dc.organizationAGS Este de Málaga-Axarquía
dc.page.number13 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2076-3921/10/11/1783/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectHydroxytyrosoles_ES
dc.subjectDiabeteses_ES
dc.subjectNephropathyes_ES
dc.subjectVirgin olive oiles_ES
dc.subjectDiabetes mellituses_ES
dc.subjectCreatininees_ES
dc.subjectOxidative stresses_ES
dc.subjectProteinuriaes_ES
dc.subjectThromboxanees_ES
dc.subjectEicosanoidses_ES
dc.subjectNefropatías diabéticases_ES
dc.subjectAceite de olivaes_ES
dc.subjectCreatininaes_ES
dc.subjectEstrés oxidativoes_ES
dc.subjectTromboxanoses_ES
dc.subjectEicosanoideses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Ratses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Nitroso Compounds::Nitrosourea Compounds::Streptozocines_ES
dc.subject.meshMedical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Experimentales_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidantses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Azoles::Imidazoles::Creatininees_ES
dc.subject.meshMedical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 1es_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stresses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Urogenital System::Urinary Tract::Kidneyes_ES
dc.subject.meshMedical Subject Headings::Diseases::Male Urogenital Diseases::Urologic Diseases::Urination Disorders::Proteinuriaes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Orales_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoreticales_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Eicosanoids::Thromboxaneses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Eicosanoidses_ES
dc.titleNephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effectes_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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