Publication:
Recomendaciones sobre el diagnóstico e informe anatomopatológico de los tumores neuroendocrinos hipofisarios. Consenso de expertos de la Sociedad Española de Endocrinologia y Nutrición y de la Sociedad Española de Anatomía Patológica.

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Date

2020-10-17

Authors

Pico, Antonio
Aranda-Lopez, Ignacio
Sesmilo, Gemma
Toldos-Gonzalez, Oscar
Japon, Miguel A
Luque, Raul M
Puig-Domingo, Manel

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Elsevier
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Abstract

Pituitary neuroendocrine tumors (PitNETs) constitute, together with other tumors of the sellar region, 15-25% of intracranial neoplasms. In 2017, the World Health Organization proposed a new classification of PitNETs. The main innovation with respect to the 2004 classification was the recommendation to include in the immunohistochemical evaluation of PitNETs the determination of the transcription factors of the 3 pituitary cell lineages: Pit-1, Tpit and SF-1. Additionally, other clinicopathological classifications with a predictive capacity of tumor behavior during follow-up were proposed. Given these changes, it is appropriate to adapt the knowledge generated during the last 15 years to the daily practice of the treatment and monitoring of PitNETs at the Centers of Excellence in Pituitary Pathology. This document includes the positioning of the Spanish Society of Endocrinology and Nutrition (SEEN) and the Spanish Society of Pathology (SEAP) on the classification and denomination of the PitNETs and the information that the pathologist should provide to the clinician to facilitate the treatment and monitoring of these tumors.

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MeSH Terms

Transcription factors
Pathologists
Cell lineage
Pituitary neoplasms
Pituitary diseases

DeCS Terms

Enfermedades de la hipófisis
Factores de transcripción
Linaje de la célula
Neoplasias hipofisarias
Patólogos

CIE Terms

Keywords

Anatomía patológica, Expert recommendations, Immunohistochemistry, Inmunohistoquímica, Neuroendocrine tumors, Pathology, Recomendaciones de expertos, Tumores neuroendocrinos

Citation

Picó A, Aranda-López I, Sesmilo G, Toldos-González Ó, Japón MA, Luque RM, et al. Recommendations on the pathological report of pituitary tumors. A consensus of experts of the Spanish Society of Endocrinology and Nutrition and the Spanish Society of Pathology. Endocrinol Diabetes Nutr (Engl Ed). 2021 Mar;68(3):196-207. English, Spanish