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Approaching Shared Pathophysiology in Immune-Mediated Diseases through Functional Genomics

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dc.contributor.authorGonzález-Serna, David
dc.contributor.authorVillanueva-Martin, Gonzalo
dc.contributor.authorAcosta-Herrera, Marialbert
dc.contributor.authorMárquez, Ana
dc.contributor.authorMartín, Javier
dc.contributor.authoraffiliation[González-Serna,D; Villanueva-Martin,G; Acosta-Herrera,M; Márquez,A; Martín,J] Institute of Parasitology and Biomedicine López-Neyra, Consejo Superior de Investigaciones Científicas (IPBLN-CSIC), Granada, Spain. [Márquez,A] Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
dc.contributor.funderThis work was supported by Red de Investigación en Inflamación y Enfermedades Reumáticas (RIER) from Instituto de Salud Carlos III (RD16/0012/0013).
dc.date.accessioned2022-07-01T12:03:48Z
dc.date.available2022-07-01T12:03:48Z
dc.date.issued2020-12-09
dc.description.abstractImmune-mediated diseases (IMDs) are complex pathologies that are strongly influenced by environmental and genetic factors. Associations between genetic loci and susceptibility to these diseases have been widely studied, and hundreds of risk variants have emerged during the last two decades, with researchers observing a shared genetic pattern among them. Nevertheless, the pathological mechanism behind these associations remains a challenge that has just started to be understood thanks to functional genomic approaches. Transcriptomics, regulatory elements, chromatin interactome, as well as the experimental characterization of genomic findings, constitute key elements in the emerging understandings of how genetics affects the etiopathogenesis of IMDs. In this review, we will focus on the latest advances in the field of functional genomics, centering our attention on systemic rheumatic IMDs.es_ES
dc.description.versionYeses_ES
dc.identifier.citationGonzález-Serna D, Villanueva-Martin G, Acosta-Herrera M, Márquez A, Martín J. Approaching Shared Pathophysiology in Immune-Mediated Diseases through Functional Genomics. Genes. 2020 Dec 9;11(12):1482es_ES
dc.identifier.doi10.3390/genes11121482es_ES
dc.identifier.essn2073-4425
dc.identifier.pmcPMC7762979
dc.identifier.pmid33317201es_ES
dc.identifier.urihttp://hdl.handle.net/10668/3731
dc.journal.titleGenes
dc.language.isoen
dc.page.number13 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/2073-4425/11/12/1482/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectFunctional genomicses_ES
dc.subjectImmune-mediated diseaseses_ES
dc.subjectTrancriptomicses_ES
dc.subjectGWASes_ES
dc.subjectHi-Ces_ES
dc.subjectShared geneticses_ES
dc.subjectGenómicaes_ES
dc.subjectInmunidad celulares_ES
dc.subjectEstudio de asociación del genoma completoes_ES
dc.subjectGenéticaes_ES
dc.subjectPerfilación de la expresión génicaes_ES
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomics::Epigenomicses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Expression Profilinges_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genetic Locies_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Diseasees_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Genetic Association Studies::Genome-Wide Association Studyes_ES
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Genomicses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Diseases::Immune System Diseaseses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Base Sequence::Regulatory Sequences, Nucleic Acides_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Transcriptomees_ES
dc.titleApproaching Shared Pathophysiology in Immune-Mediated Diseases through Functional Genomicses_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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