Publication:
The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes

Simple item page
dc.contributor.authorCamarillo, Rosa
dc.contributor.authorJimeno, Sonia
dc.contributor.authorHuertas, Pablo
dc.contributor.authoraffiliation[Camarillo,R: Jimeno,S; Huertas,P] Departamento de Genética, Universidad de Sevilla, Sevilla, Spain. [Camarillo,R: Jimeno,S; Huertas,P] Centro Andaluz de Biología Molecular y Medicina Regenerativa-CABIMER, Universidad de Sevilla-CSIC-Universidad Pablo de Olavide, Sevilla, Spain.
dc.contributor.funderThis work was funded by the R + D + I grant PID 2019-104195G from the Spanish Ministry of Science and Innovation-Agencia Estatal de Investigación/10.13039/501100011033. RC-D is funded by an FPI fellowships from the Spanish Ministry of Science. CABIMER is supported by the regional government of Andalucia (Junta de Andalucía).
dc.date.accessioned2022-09-21T06:54:03Z
dc.date.available2022-09-21T06:54:03Z
dc.date.issued2021-10-08
dc.description.abstractThe fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.es_ES
dc.description.versionYeses_ES
dc.identifier.citationCamarillo R, Jimeno S, Huertas P. The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes. Front Genet. 2021 Oct 8;12:742434.es_ES
dc.identifier.doi10.3389/fgene.2021.742434es_ES
dc.identifier.essn1664-8021
dc.identifier.pmcPMC8531813
dc.identifier.pmid34691154es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4085
dc.journal.titleFrontiers in Genetics
dc.language.isoen
dc.page.number10 p.
dc.publisherFrontierses_ES
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fgene.2021.742434/fulles_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectR-loopses_ES
dc.subjectDNA double strand break repaires_ES
dc.subjectHomologous recombination (HR)es_ES
dc.subjectDNA end resectiones_ES
dc.subjectG-quadruplexes_ES
dc.subjectEstructuras R-loopes_ES
dc.subjectRecombinación homólogaes_ES
dc.subjectG-cuádruplexes_ES
dc.subjectADNes_ES
dc.subjectARNes_ES
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Cueses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation::Nucleic Acid Conformation::G-Quadruplexeses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Recombination, Genetic::Homologous Recombinationes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acidses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Nucleic Acid Conformation::DNA, B-Formes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Biological Phenomenaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::DNAes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Nucleic Acid Conformation::G-Quadruplexeses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNAes_ES
dc.titleThe Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexeses_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
Camarillo_TheEffect.pdf
Size:
1.08 MB
Format:
Adobe Portable Document Format
Description:
Artículo publicado
Download

Collections

Centro Andaluz de Biología Molecular (CABIMER)

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía