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Impact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation.

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dc.contributor.authorCunha, Renato
dc.contributor.authorZago, Marco A
dc.contributor.authorQuerol, Sergio
dc.contributor.authorVolt, Fernanda
dc.contributor.authorRuggeri, Annalisa
dc.contributor.authorSanz, Guillermo
dc.contributor.authorPouthier, Fabienne
dc.contributor.authorKogler, Gesine
dc.contributor.authorVicario, José L
dc.contributor.authorBergamaschi, Paola
dc.contributor.authorSaccardi, Riccardo
dc.contributor.authorLamas, Carmen H
dc.contributor.authorDíaz-de-Heredia, Cristina
dc.contributor.authorMichel, Gerard
dc.contributor.authorBittencourt, Henrique
dc.contributor.authorTavella, Marli
dc.contributor.authorPanepucci, Rodrigo A
dc.contributor.authorFernandes, Francisco
dc.contributor.authorPavan, Julia
dc.contributor.authorGluckman, Eliane
dc.contributor.authorRocha, Vanderson
dc.contributor.authorEurocord, Cord Blood Committee Cellular Therapy–Immunobiology Working Party of the European Society for Blood and Marrow Transplantation, Netcord and Faculdade de Medicina de Ribeirão Preto–Faculdade de Medicina de São Paulo, Universidade de São Paulo
dc.date.accessioned2023-01-25T08:38:49Z
dc.date.available2023-01-25T08:38:49Z
dc.date.issued2016-11-03
dc.description.abstractWe evaluated the impact of recipient and cord blood unit (CBU) genetic polymorphisms related to immune response on outcomes after unrelated cord blood transplantations (CBTs). Pretransplant DNA samples from 696 CBUs with malignant diseases were genotyped for NLRP1, NLRP2, NLRP3, TIRAP/Mal, IL10, REL, TNFRSF1B, and CTLA4. HLA compatibility was 6 of 6 in 10%, 5 of 6 in 39%, and ≥4 of 6 in 51% of transplants. Myeloablative conditioning was used in 80%, and in vivo T-cell depletion in 81%, of cases. The median number of total nucleated cells infused was 3.4 × 107/kg. In multivariable analysis, patients receiving CBUs with GG-CTLA4 genotype had poorer neutrophil recovery (hazard ratio [HR], 1.33; P = .02), increased nonrelapse mortality (NRM) (HR, 1.50; P
dc.identifier.doi10.1182/blood-2016-06-722249
dc.identifier.essn1528-0020
dc.identifier.pmid27811020
dc.identifier.unpaywallURLhttps://ashpublications.org/blood/article-pdf/129/4/525/1402196/blood722249.pdf
dc.identifier.urihttp://hdl.handle.net/10668/10578
dc.issue.number4
dc.journal.titleBlood
dc.journal.titleabbreviationBlood
dc.language.isoen
dc.organizationBiobanco del Sistema Sanitario Público de Andalucía
dc.page.number525-532
dc.pubmedtypeJournal Article
dc.rights.accessRightsopen access
dc.subject.meshAdaptor Proteins, Signal Transducing
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAlleles
dc.subject.meshApoptosis Regulatory Proteins
dc.subject.meshCTLA-4 Antigen
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCord Blood Stem Cell Transplantation
dc.subject.meshDisease-Free Survival
dc.subject.meshFemale
dc.subject.meshFetal Blood
dc.subject.meshGene Expression
dc.subject.meshGenotype
dc.subject.meshHLA Antigens
dc.subject.meshHematologic Neoplasms
dc.subject.meshHistocompatibility Testing
dc.subject.meshHumans
dc.subject.meshInfant
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMyeloablative Agonists
dc.subject.meshNLR Proteins
dc.subject.meshPolymorphism, Genetic
dc.subject.meshProportional Hazards Models
dc.subject.meshProtein Isoforms
dc.subject.meshRetrospective Studies
dc.subject.meshTransplantation Conditioning
dc.subject.meshUnrelated Donors
dc.titleImpact of CTLA4 genotype and other immune response gene polymorphisms on outcomes after single umbilical cord blood transplantation.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number129
dspace.entity.typePublication

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