Publication:
Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial

dc.contributor.authorSchoisswohl, Stefan
dc.contributor.authorLangguth, Berthold
dc.contributor.authorSchecklmann, Martin
dc.contributor.authorBernal-Robledano, Alberto
dc.contributor.authorBoecking, Benjamin
dc.contributor.authorCederroth, Christopher R.
dc.contributor.authorChalanouli, Dimitra
dc.contributor.authorCima, Rilana
dc.contributor.authorDenys, Sam
dc.contributor.authorDettling-Papargyris, Juliane
dc.contributor.authorEscalera-Balsera, Alba
dc.contributor.authorEspinosa-Sanchez, Juan Manuel
dc.contributor.authorGallego-Martinez, Alvaro
dc.contributor.authorGiannopoulou, Efi
dc.contributor.authorHidalgo-Lopez, Leyre
dc.contributor.authorHummel, Michael
dc.contributor.authorKikidis, Dimitris
dc.contributor.authorKoller, Michael
dc.contributor.authorLopez-Escamez, Jose A.
dc.contributor.authorMarcrum, Steven C.
dc.contributor.authorMarkatos, Nikolaos
dc.contributor.authorMartin-Lagos, Juan
dc.contributor.authorMartinez-Martinez, Maria
dc.contributor.authorMartinez-Martinez, Marta
dc.contributor.authorMata Ferron, Maria
dc.contributor.authorMazurek, Birgit
dc.contributor.authorMueller-Locatelli, Nicolas
dc.contributor.authorNeff, Patrick
dc.contributor.authorOppel, Kevin
dc.contributor.authorPerez-Carpena, Patricia
dc.contributor.authorRobles-Bolivar, Paula
dc.contributor.authorRose, Matthias
dc.contributor.authorSchiele, Tabea
dc.contributor.authorSchiller, Axel
dc.contributor.authorSimoes, Jorge
dc.contributor.authorStark, Sabine
dc.contributor.authorStaudinger, Susanne
dc.contributor.authorStege, Alexandra
dc.contributor.authorVerhaert, Nicolas
dc.contributor.authorSchlee, Winfried
dc.contributor.authoraffiliation[Schoisswohl,S; Langguth,B; Schecklmann,M; Neff,P; Schiller,A; Simoes,J; Staudinger,S; Schlee,W] Department of Psychiatry and Psychotherapy, University of Regensburg, Regensburg, Germany. [Bernal-Robledano,A; Espinosa-Sanchez,JM; Lopez-Escamez,JA; Martinez-Martinez,M; Martinez-Martinez,M; Mata Ferron,M; Perez-Carpena,P] Department of Otolaryngology, Instituto de Investigacion Biosanitaria Ibs.GRANADA, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Boecking,B; Mazurek,B; Schiele,T; Stark,S] Tinnitus Center, Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt Universität Berlin, Berlin, Germany. [Cederroth,CR] Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. [Chalanouli,D; Giannopoulou,E] EXCELYA Hungary Kft., Budakalász, Hungary. [Cima,R] Department of Health Psychology, Katholieke Universiteit Leuven, Leuven, Belgium. [Denys,S; Verhaert,N] Department of Neurosciences, Research group Experimental Oto-Rhino-Laryngology, University of Leuven, Leuven, Belgium. [Denys,S; Verhaert,N] Department of Otorhinolaryngology - Head and Neck surgery, University Hospitals Leuven, Leuven, Belgium. [Denys,S; Verhaert,N] Multidisciplinary University Center for Speech-Language Pathology and Audiology, University Hospitals Leuven, Leuven, Belgium. [Dettling-Papargyris,J; Oppel,K] Terzo-Institute for Applied Hearing Research, ISMA, Sonneberg, Germany. [Escalera-Balsera,A; Espinosa-Sanchez,JM; Gallego-Martinez,A; Lopez-Escamez,JA; Martinez-Martinez,M; Mata Ferron,M; Perez-Carpena,P; Robles-Bolivar,P] Otology & Neurotology Group CTS 495, Department of Genomic Medicine, GENYO, Center for Genomics and Oncological Research: Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Granada, Spain. [Hidalgo-Lopez,L] Department of Mental Health, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Hummel,M; Stege,A] Central Biobank Charité, Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt Universität Berlin, Berlin, Germany. [Kikidis,D; Markatos,N] Department of Otolaryngology, Head and Neck Surgery, National and Kapodistrian University of Athens, Hippocrateion General Hospital, Athens, Greece. [Koller,M] Center for Clinical Studies, University Hospital Regensburg, Regensburg, Germany. [Lopez-Escamez,JA] Department of Surgery, Division of Otolaryngology, Universidad de Granada, Granada, Spain. [Marcrum,SC] Department of Otolaryngology, University Hospital Regensburg, Regensburg, Germany. [Martin-Lagos,J; Martinez-Martinez,M; Mueller-Locatelli,N] Department of Otolaryngology, Instituto de Investigacion Biosanitaria ibs. GRANADA, Hospital Universitario Clinico San Cecilio, Granada, Spain. [Neff,P] Center for Cognitive Neuroscience and Department of Psychology, University of Salzburg, Salzburg, Austria. [Rose,M] epartment of Psychosomatic and Psychotherapy, Charité- Universitätsmedizin Berlin, corporate member of Freie Universität Berlin und Humboldt Universität Berlin, Berlin, Germany.
dc.contributor.funderThe UNITI project has received funding from the European Union’s Horizon2020 Research and Innovation Program (grant agreement number 848261). Open Access funding enabled and organized by Projekt DEAL.
dc.date.accessioned2022-09-12T09:11:59Z
dc.date.available2022-09-12T09:11:59Z
dc.date.issued2021-12-04
dc.description.abstractTinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden in many cases. Nevertheless, there is currently no general treatment or cure, presumable due to the heterogeneity of tinnitus with its wide variety of etiologies and tinnitus phenotypes. Hence, most treatment studies merely demonstrated improvement in a subgroup of tinnitus patients. The majority of studies are characterized by small sample sizes, unstandardized treatments and assessments, or applications of interventions targeting only a single organ level. Combinatory treatment approaches, potentially targeting multiple systems as well as treatment personalization, might provide remedy and enhance treatment responses. The aim of the present study is to systematically examine established tinnitus therapies both alone and in combination in a large sample of tinnitus patients. Further, it wants to provide the basis for personalized treatment approaches by evaluating a specific decision support system developed as part of an EU-funded collaborative project (Unification of treatments and interventions for tinnitus patients; UNITI project).es_ES
dc.description.versionYeses_ES
dc.identifier.citationSchoisswohl S, Langguth B, Schecklmann M, Bernal-Robledano A, Boecking B, Cederroth CR, Chalanouli D, Cima R, Denys S, Dettling-Papargyris J, Escalera-Balsera A, Espinosa-Sanchez JM, Gallego-Martinez A, Giannopoulou E, Hidalgo-Lopez L, Hummel M, Kikidis D, Koller M, Lopez-Escamez JA, Marcrum SC, Markatos N, Martin-Lagos J, Martinez-Martinez M, Martinez-Martinez M, Ferron MM, Mazurek B, Mueller-Locatelli N, Neff P, Oppel K, Perez-Carpena P, Robles-Bolivar P, Rose M, Schiele T, Schiller A, Simoes J, Stark S, Staudinger S, Stege A, Verhaert N, Schlee W. Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial. Trials. 2021 Dec 4;22(1):875es_ES
dc.identifier.doi10.1186/s13063-021-05835-zes_ES
dc.identifier.essn1745-6215
dc.identifier.pmcPMC8642746
dc.identifier.pmid34863270es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4032
dc.journal.titleTrials
dc.language.isoen
dc.page.number16 p.
dc.publisherBioMed Centrales_ES
dc.relation.publisherversionhttps://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05835-zes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectTinnituses_ES
dc.subjectTreatmentes_ES
dc.subjectHearing aidses_ES
dc.subjectCognitive behavioral therapyes_ES
dc.subjectSound therapyes_ES
dc.subjectStructured counselinges_ES
dc.subjectMulti-centeres_ES
dc.subjectRCTes_ES
dc.subjectAcúfenoes_ES
dc.subjectTerapéuticaes_ES
dc.subjectAudífonoses_ES
dc.subjectTerapia cognitivo-conductuales_ES
dc.subjectTerapia de sonidoses_ES
dc.subjectEnsayos clínicos controlados no aleatorios como asuntoes_ES
dc.subjectConsejoes_ES
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Psychology, Applied::Counselinges_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Multicenter Studies as Topices_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Clinical Trials as Topic::Controlled Clinical Trials as Topic::Randomized Controlled Trials as Topices_ES
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychotherapy::Behavior Therapy::Cognitive Therapyes_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Equipment and Supplies::Sensory Aids::Hearing Aidses_ES
dc.subject.meshMedical Subject Headings::Diseases::Otorhinolaryngologic Diseases::Ear Diseases::Hearing Disorders::Tinnituses_ES
dc.titleUnification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical triales_ES
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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