Publication:
Single nucleotide polymorphisms as prognostic and predictive biomarkers in renal cell carcinoma

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dc.contributor.authorGarrigos, Carmen
dc.contributor.authorEspinosa, Marta
dc.contributor.authorSalinas, Ana
dc.contributor.authorOsman, Ignacio
dc.contributor.authorMedina, Rafael
dc.contributor.authorTaron, Miguel
dc.contributor.authorMolina-Pinelo, Sonia
dc.contributor.authorDuran, Ignacio
dc.contributor.authoraffiliation[Garrigos, Carmen] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Seville, Spain
dc.contributor.authoraffiliation[Espinosa, Marta] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Seville, Spain
dc.contributor.authoraffiliation[Salinas, Ana] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Seville, Spain
dc.contributor.authoraffiliation[Taron, Miguel] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Seville, Spain
dc.contributor.authoraffiliation[Molina-Pinelo, Sonia] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Seville, Spain
dc.contributor.authoraffiliation[Duran, Ignacio] Univ Seville, CSIC, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla, Seville, Spain
dc.contributor.authoraffiliation[Osman, Ignacio] Univ Seville, UGC Urol Nefrolo, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla,CSIC,Unidad Urol Oncol, Seville, Spain
dc.contributor.authoraffiliation[Medina, Rafael] Univ Seville, UGC Urol Nefrolo, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla,CSIC,Unidad Urol Oncol, Seville, Spain
dc.contributor.authoraffiliation[Molina-Pinelo, Sonia] CIBERONC, Ctr Invest Biomed Red Canc, Madrid, Spain
dc.contributor.funderAndalusian Government
dc.date.accessioned2023-02-12T02:24:03Z
dc.date.available2023-02-12T02:24:03Z
dc.date.issued2017-12-05
dc.description.abstractDespite major advances in the knowledge of the molecular basis of renal cell carcinoma, prognosis is still defined using clinical and pathological parameters. Moreover, no valid predictive biomarkers exist to help us selecting the best treatment for each patient. With these premises, we aimed to analyse the expression and to determine the prognostic and predictive value of 64 key single nucleotide polymorphisms in 18 genes related with angiogenesis or metabolism of antiangiogenics in two cohorts of patients with localized and advanced renal cell cancer treated at our institution. The presence of the selected single nucleotide polymorphisms was correlated with clinical features, disease free survival, overall survival and response rate. In patients with localized renal cell cancer, 5 of these polymorphisms in 3 genes involved in angiogenesis predicted for worse disease free survival (VEGFR2: rs10013228; PDGFRA: rs2228230) or shorter overall survival (VEGFR2: rs10013228; VEGFR3: rs6877011, rs307826) (p
dc.identifier.doi10.18632/oncotarget.22533
dc.identifier.essn1949-2553
dc.identifier.unpaywallURLhttps://www.oncotarget.com/article/22533/pdf/
dc.identifier.urihttp://hdl.handle.net/10668/19449
dc.identifier.wosID419534900048
dc.issue.number63
dc.journal.titleOncotarget
dc.journal.titleabbreviationOncotarget
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number106551-106564
dc.publisherImpact journals llc
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectsingle nucleotide polymorphisms
dc.subjectangiogenesis genes
dc.subjectbiomarkers
dc.subjectlocalized renal cell carcinoma
dc.subjectadvanced renal cell carcinoma
dc.subjectSunitinib
dc.subjectEfficacy
dc.subjectCancer
dc.subjectAngiogenesis
dc.subjectMarkers
dc.subjectTumor
dc.subjectVegf
dc.subjectIdentification
dc.subjectAssociations
dc.subjectPazopanib
dc.titleSingle nucleotide polymorphisms as prognostic and predictive biomarkers in renal cell carcinoma
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number8
dc.wostypeArticle
dspace.entity.typePublication

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