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Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma

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dc.contributor.authorManzano-Moreno, Francisco Javier
dc.contributor.authorCostela-Ruiz, Victor J.
dc.contributor.authorGarcía-Recio, Enrique
dc.contributor.authorOlmedo-Gaya, Maria Victoria
dc.contributor.authorRuiz, Concepción
dc.contributor.authorReyes-Botella, Candelaria
dc.contributor.authoraffiliation[Manzano-Moreno,FJ; Reyes-Botella,C] Biomedical Group (BIO277), Department of Stomatology, School of Dentistry, University of Granada, Granada, Spain. [Manzano-Moreno,FJ; Costela-Ruiz,VJ; García-Recio,E; Ruiz,C; Reyes-Botella,C] Instituto Investigación Biosanitaria, ibs.Granada, Granada, Spain. [Costela-Ruiz,VJ] Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, Campus de Ceuta, University of Granada, Ceuta, Spain. [García-Recio,E] Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, Campus de Melilla, University of Granada, Melilla, Spain. [Olmedo-Gaya,MV] Department of Stomatology, School of Dentistry, University of Granada, Granada, Spain. [Ruiz,C] Biomedical Group (BIO277), Department of Nursing, Faculty of Health Sciences, University of Granada,Granada, Spain. [Ruiz,C] Institute of Neuroscience, University of Granada, Granada, Spain
dc.date.accessioned2022-09-27T06:22:26Z
dc.date.available2022-09-27T06:22:26Z
dc.date.issued2021-11-11
dc.description.abstractOral squamous cell carcinoma (OSCC) is the most prevalent oral malignant tumor worldwide. An early diagnosis can have a major positive impact on its prognosis. Human saliva contains cytokines, DNA and RNA molecules, circulating cells, and derivatives of tissues and extracellular vesicles, among other factors that can serve as biomarkers. Hence, the analysis of saliva may provide useful information for the early diagnosis of OSCC for its prognosis. The objective of this review was to determine the potential usefulness of salivary biomarkers (cytokines and microRNA) to diagnose OSCC and improve its prognosis. A combination of salivary miRNA and proteomic data could allow a definitive and early diagnosis to be obtained. However, there remains a need to optimize and standardize the protocols used to quantify miRNAs.es_ES
dc.description.versionYeses_ES
dc.identifier.citationManzano-Moreno FJ, Costela-Ruiz VJ, García-Recio E, Olmedo-Gaya MV, Ruiz C, Reyes-Botella C. Role of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinoma. Int J Mol Sci. 2021 Nov 11;22(22):12215es_ES
dc.identifier.doi10.3390/ijms222212215es_ES
dc.identifier.essn1422-0067
dc.identifier.pmcPMC8624198
dc.identifier.pmid34830096es_ES
dc.identifier.urihttp://hdl.handle.net/10668/4153
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isoen
dc.page.number13 p.
dc.publisherMDPIes_ES
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/22/22/12215/htmes_ES
dc.rightsAtribución 4.0 Internacional*
dc.rights.accessRightsAcceso abiertoes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSalivary biomarkeres_ES
dc.subjectmicroRNAes_ES
dc.subjectCytokineses_ES
dc.subjectOral pathologyes_ES
dc.subjectDiagnosises_ES
dc.subjectOral canceres_ES
dc.subjectSquamous cell carcinomaes_ES
dc.subjectBiomarcadoreses_ES
dc.subjectMicroARNses_ES
dc.subjectPatología bucales_ES
dc.subjectDiagnósticoes_ES
dc.subjectNeoplasias de la bocaes_ES
dc.subjectCarcinoma de células escamosases_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokineses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Neoplasm Proteinses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosises_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Neoplasmes_ES
dc.subject.meshMedical Subject Headings::Anatomy::Fluids and Secretions::Bodily Secretions::Salivaes_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Salivary Proteins and Peptideses_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Head and Neck Neoplasms::Mouth Neoplasmses_ES
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Neoplasms, Squamous Cell::Carcinoma, Squamous Celles_ES
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Proteomicses_ES
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Early Diagnosises_ES
dc.subject.meshMedical Subject Headings::Information Science::Information Science::Communications Media::Publications::Review Literature as Topices_ES
dc.titleRole of Salivary MicroRNA and Cytokines in the Diagnosis and Prognosis of Oral Squamous Cell Carcinomaes_ES
dc.typereview article
dc.type.hasVersionVoR
dspace.entity.typePublication

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