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Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus.

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dc.contributor.authorGarcía-Fontana, Beatriz
dc.contributor.authorMorales-Santana, Sonia
dc.contributor.authorLongobardo, Victoria
dc.contributor.authorReyes-García, Rebeca
dc.contributor.authorRozas-Moreno, Pedro
dc.contributor.authorGarcía-Salcedo, José Antonio
dc.contributor.authorMuñoz-Torres, Manuel
dc.contributor.authoraffiliation[García-Fontana,B; Morales-Santana,S; Reyes-García,R; Muñoz-Torres,M] Bone Metabolic Unit, Endocrinology Division (RETICEF), Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Granada, Spain. [Morales-Santana,S] Proteomic Research Service, Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Granada, Spain. [Longobardo,V] Proteomic Research Service, Institute of Parasitology and Biomedicine “López Neyra” (C.S.I.C.), Granada, Spain. [Rozas-Moreno,P] Endocrinology Division, Ciudad Real General Hospital, Ciudad Real, Spain. [García-Salcedo,JA] Infectious Diseases Unit, Instituto de Investigación Biosanitaria (Ibs) Granada, University Hospital San Cecilio, Granada, Spain. [Muñoz-Torres,M] Endocrinology Unit, University Hospital San Cecilio, Spain.es
dc.contributor.funderThis work was support in part by Consejería de Salud y Bienestar Social (Junta de Andalucía) Grant (PI05142012), RETICEF (RD06/0013/1014-RD12/0043/0014) and Fondo de Investigación Sanitaria (Instituto Carlos III) Grants (PI12/02141) with co-financing from FEDER (Fondo Europeo de Desarrollo Regional).
dc.date.accessioned2016-10-21T09:18:57Z
dc.date.available2016-10-21T09:18:57Z
dc.date.issued2015-04-27
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractType 2 diabetes mellitus patients are at significant risk of cardiovascular disease, however, the pathophysiology of these complications is complex and incompletely known in this population. The aim of this study was to compare the serum proteome of patients with type 2 diabetes mellitus presenting or not presenting cardiovascular disease with non-diabetic subjects to find essential proteins related to these cardiovascular complications. This cross-sectional study compares the serum proteome by a combination of protein depletion with 2D-DIGE (2-dimension Difference Gel Electrophoresis) methodology. The proteins differentially expressed were identified by MALDI TOF/TOF (Matrix-assisted laser desorption/ionization and Time-Of-Flight ion detector) or LC-MS/MS (Liquid Chromatography coupled to Mass-Mass Spectrometry). Type 2 diabetes mellitus patients with cardiovascular disease showed higher expression of plasma retinol binding protein and glutathione peroxidase-3 compared to those without cardiovascular disease and non-diabetic controls. These results show that proteins related to the inflammatory and redox state appear to play an important role in the pathogenesis of the cardiovascular disease in the type 2 diabetes mellitus patients.es
dc.description.versionYeses
dc.identifier.citationGarcía-Fontana B, Morales-Santana S, Longobardo V, Reyes-García R, Rozas-Moreno P, García-Salcedo JA, et al. Relationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus. Int J Mol Sci. 2015; 16(5):9469-83es
dc.identifier.doi10.3390/ijms16059469
dc.identifier.essn1422-0067
dc.identifier.pmcPMC4463599
dc.identifier.pmid25923078
dc.identifier.urihttp://hdl.handle.net/10668/2482
dc.journal.titleInternational Journal of Molecular Sciences
dc.language.isospa
dc.publisherMDPIes
dc.relation.publisherversionhttp://www.mdpi.com/1422-0067/16/5/9469es
dc.rights.accessRightsopen access
dc.subjectCardiovascular diseasees
dc.subjectType 2 diabetes mellituses
dc.subjectProinflammationes
dc.subjectOxidative stresses
dc.subjectProteomices
dc.subjectAntioxidanteses
dc.subjectBiomarcadoreses
dc.subjectEnfermedades cardiovasculareses
dc.subjectCromatografía liquidaes
dc.subjectDiabetes mellitus tipo 2es
dc.subjectHumanoses
dc.subjectElectroforesis bidimensional diferencial en geles
dc.subjectEstrés oxidativoes
dc.subjectProteómicaes
dc.subjectEspectrometría de masa por láser de matriz asistida de ionización desorciónes
dc.subjectEspectrometría de masas en tándemes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Anthropometryes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidantses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Chromatography::Chromatography, Liquides
dc.subject.meshMedical Subject Headings::Diseases::Cardiovascular Diseaseses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biomarkerses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cross-Sectional Studieses
dc.subject.meshMedical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Complicationses
dc.subject.meshMedical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2es
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Peroxidases::Glutathione Peroxidasees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammationes
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Physicochemical Processes::Oxidation-Reductiones
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stresses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosises
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biochemistry::Proteomicses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Health Surveys::Health Status Indicators::Severity of Illness Indexes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry::Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionizationes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Mass Spectrometry::Tandem Mass Spectrometryes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Chemistry Techniques, Analytical::Electrophoresis::Electrophoresis, Gel, Two-Dimensional::Two-Dimensional Difference Gel Electrophoresises
dc.titleRelationship between Proinflammatory and Antioxidant Proteins with the Severity of Cardiovascular Disease in Type 2 Diabetes Mellitus.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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