Publication:
Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study.

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Date

2022-07-16

Authors

Riquelme-Gallego, Blanca
Garcia-Molina, Laura
Cano-Ibañez, Naomi
Andujar-Vera, Francisco
Gonzalez-Salvatierra, Sheila
Garcia-Fontana, Cristina
Bueno-Cavanillas, Aurora
Muñoz-Torres, Manuel
Garcia-Fontana, Beatriz

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MDPI AG
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Lifestyle changes are causing an exponential increase in the prevalence of obesity and metabolic syndrome (MetS) worldwide. The most frequent complications of these are the development of diabetes (T2D) and cardiovascular disease (CVD). Accurate tools are needed to classify the cardiovascular risk (CVR) in the MetS population. In recent years, numerous biomarkers of bone metabolism have been associated with CVR. The aim of this study was to determine the levels of undercarboxylated osteocalcin (ucOC) in a cohort of patients with MetS and to analyse its association with MetS parameters and CVR as well as with T2D prevalence. A longitudinal study was conducted in which a MetS population was followed for one year. Weight change, adherence to the Mediterranean diet (MedDiet), ucOC levels, MetS parameters and CVR were analysed and CVR was calculated using different scores. Our results showed a decrease of CVR associated with a better adherence to the MetDiet resulting in higher HDL-C and ucOC levels though the improvement of MetS risk factors. This bone protein appeared as a potential biomarker to classify CVR in the MetS population, especially for MetS patients without prevalent T2D. Furthermore, ucOC serum levels could be good predictors of T2D prevalence.

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MeSH Terms

Biomarkers
Blood Glucose
Diabetes Mellitus, Type 2
Early Diagnosis
Humans
Longitudinal Studies
Metabolic Syndrome
Osteocalcin
Pilot Projects
Risk Factors

DeCS Terms

Biomarcadores
Diabetes Mellitus tipo 2
Diagnóstico precoz
Estudios longitudinales
Factores de riesgo
Glucemia
Humanos
Osteocalcina
Proyectos piloto
Síndrome metabólico

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Keywords

Mediterranean diet, cardiovascular risk, diabetes, metabolic syndrome, osteocalcin

Citation

Riquelme-Gallego B, García-Molina L, Cano-Ibáñez N, Andújar-Vera F, González-Salvatierra S, García-Fontana C, et al. Undercarboxylated Osteocalcin: A Promising Target for Early Diagnosis of Cardiovascular and Glycemic Disorders in Patients with Metabolic Syndrome: A Pilot Study. Nutrients. 2022 Jul 21;14(14):2991.