Publication: Assessing bone quality through mechanical properties in postmenopausal trabecular bone.
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Identifiers
Date
2018
Authors
Toledano, Manuel
Toledano-Osorio, Manuel
Guerado, Enrique
Caso, Enrique
Osorio, Estrella
Osorio, Raquel
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The inner structure of trabecular bone is a result of structural optimization provided by remodeling processes. Changes in hormonal status related to menopause cause bone tissue loss and micro-architectural deterioration with a consequent susceptibility to fracture. Accumulation of micro-damage in bone, as a function of the rate of production and rate of repair, underlies the development of stress fractures, increasing fragility associated to age and osteoporosis, especially in transmenopausal women. Quasi-static and nano-dynamic mechanical characterization were undertaken in trabecular bone from femoral neck biopsies of postmenopausal women. AFM (Atomic Force Microscopy) complementary studies were performed to determine nano-roughness (SRa) and the fibrils width of collagen. Nanoindentations were used to quantify transmenopausal changes in intrinsic mechanical properties of trabecular bone: hardness (Hi), modulus of Young (Ei), complex modulus (E*), tan delta (δ), storage modulus (E') and loss modulus (E"). As result of the quasi-static measurements, 0.149 (0.036) GPa and 2.95 (0.73) GPa of Hi and Ei were obtained, respectively. As result of the nano-dynamic measurements, 17.94 (3.15), 0.62 (0.10), 13.79 (3.21 and 6.39 (1.28) GPa of E*, tan (δ), E' and E" were achieved, respectively. 101.07 SRa and 831.28 nm of fibrils width were additionally obtained. This study poses a first approach to the measurement of bone quality in postmenopausal trabecular bone by combining quasi-static, nano-DMA analysis and tribology of dentin surface through AFM characterization.
Description
MeSH Terms
Biomechanical Phenomena
Bone Density
Cancellous Bone
Elasticity
Female
Femur Neck
Hardness
Humans
Microscopy, Atomic Force
Middle Aged
Osteoporosis, Postmenopausal
Postmenopause
Bone Density
Cancellous Bone
Elasticity
Female
Femur Neck
Hardness
Humans
Microscopy, Atomic Force
Middle Aged
Osteoporosis, Postmenopausal
Postmenopause
DeCS Terms
CIE Terms
Keywords
Dynamic, Mechanic, Menopause, Static, Trabecular bone