Publication: El ácido ursodexosicólico disminuye el riesgo de mocroangiopatía trombótica tras traspante de progenitores hematopoyéticos
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Identifiers
Date
2015-10-22
Authors
Ruiz Mercado, M
López Godino, O
Martínez, C
Solano, C
Parody, R
López Corral, L
Fernández-Avilés, F
Herrera, JC
Márquez-Malaver, FJ
Caballero, D
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Ferrata Storti Foundation
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Abstract
Fundamentos y/o objetivos: La microangiopatía trombótica (MAT) es una complicación grave tras el trasplante alogénico de progenitores hematopoyéticos (AloTPH). El daño endotelial en la MAT se traduce en concentraciones elevadas de FvW o endotelina, entre otros. El ácido ursodesoxicólico (AU) ejerce una acción inmunomoduladora y anti-inflamatoria inhibiendo la endotelina y el NF-κb y promoviendo la producción de óxido nítrico. Con estas premisas, el objetivo del estudio
fue analizar la incidencia y factores de riesgo de MAT e identificar el posible
papel protector del AU en el desarrollo de MAT.
Description
LVII Congreso Nacional De La Sociedad Española De Hematología Y Hemoterapia, Valencia, Spain, 22–24 De Octubre, 2015
MeSH Terms
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::NF-kappa B
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Acyclic::Alkenes::Polyenes::Carotenoids::Retinoids::Vitamin A::Tretinoin
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Endothelins
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Nitric Oxide
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Blood Platelet Disorders::Thrombocytopenia::Thrombotic Microangiopathies
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Bile Acids and Salts::Cholic Acids::Deoxycholic Acid::Ursodeoxycholic Acid
Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Acyclic::Alkenes::Polyenes::Carotenoids::Retinoids::Vitamin A::Tretinoin
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Endothelins
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Surgical Procedures, Operative::Transplantation::Cell Transplantation::Stem Cell Transplantation::Hematopoietic Stem Cell Transplantation
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Incidence
Medical Subject Headings::Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Nitric Oxide
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors
Medical Subject Headings::Diseases::Hemic and Lymphatic Diseases::Hematologic Diseases::Blood Platelet Disorders::Thrombocytopenia::Thrombotic Microangiopathies
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Bile Acids and Salts::Cholic Acids::Deoxycholic Acid::Ursodeoxycholic Acid
DeCS Terms
CIE Terms
Keywords
Microangiopatía trombótica, Progenitores hematopoyéticos, Endotelina, Óxido nítrico
Citation
Ruiz Mercado M, López Godino O, Martínez C, Solano C, Parody R, López Corral L, et al. El ácido ursodexosicólico disminuye el riesgo de mocroangiopatía trombótica tras traspante de progenitores hematopoyéticos. Haematologica.2015; vol.100, suplemt.4 , CO-073