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High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.

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dc.contributor.authorSan-Juan, Rafael
dc.contributor.authorViedma, Esther
dc.contributor.authorChaves, Fernando
dc.contributor.authorLalueza, Antonio
dc.contributor.authorFortún, Jesús
dc.contributor.authorLoza, Elena
dc.contributor.authorPujol, Miquel
dc.contributor.authorArdanuy, Carmen
dc.contributor.authorMorales, Isabel
dc.contributor.authorde Cueto, Marina
dc.contributor.authorResino-Foz, Elena
dc.contributor.authorMorales-Cartagena, Alejandra
dc.contributor.authorRico, Alicia
dc.contributor.authorRomero, María P
dc.contributor.authorOrellana, María Ángeles
dc.contributor.authorLópez-Medrano, Francisco
dc.contributor.authorFernández-Ruiz, Mario
dc.contributor.authorAguado, José María
dc.contributor.authoraffiliation[San-Juan,R; Viedma,E; Chaves,F; Lalueza,A; Resino-Foz,E; Morales-Cartagena,A; Orellana,MA; López-Medrano,F; Fernández-Ruiz,M; Aguado,JM] University Hospital–Research Institute 12 de Octubre, Madrid, Spain. [Fortún,J; Loza,E] Hospital Universitario Ramón y Cajal, Madrid, Spain. [Pujol,M; Ardanuy,C] University Hospital–Bellvitge Institute for Biomedical Research, Barcelona, Spain. [Morales,I; de Cueto,M] Hospital Universitario Virgen de la Macarena, Seville, Spain. [Rico,A; Romero,MP] Hospital Universitario La Paz, Madrid. Spain.es
dc.date.accessioned2016-11-21T13:15:04Z
dc.date.available2016-11-21T13:15:04Z
dc.date.issued2016-06
dc.descriptionJournal Article;es
dc.description.abstractWe investigated the prognostic role of high MICs for antistaphylococcal agents in patients with methicillin-sensitive Staphylococcus aureus catheter-related bloodstream infection (MSSA CRBSI). We prospectively reviewed 83 episodes from 5 centers in Spain during April 2011-June 2014 that had optimized clinical management and analyzed the relationship between E-test MICs for vancomycin, daptomycin, oxacillin, and linezolid and development of complicated bacteremia by using multivariate analysis. Complicated MSSA CRBSI occurred in 26 (31.3%) patients; MICs for vancomycin and daptomycin were higher in these patients (optimal cutoff values for predictive accuracy = 1.5 μg/mL and 0.5 μg/mL). High MICs for vancomycin (hazard ratio 2.4, 95% CI 1.2-5.5) and daptomycin (hazard ratio 2.4, 95% CI 1.1-5.9) were independent risk factors for development of complicated MSSA CRBSI. Our data suggest that patients with MSSA CRBSI caused by strains that have high MICs for vancomycin or daptomycin are at increased risk for complications.es
dc.description.versionYeses
dc.identifier.citationSan-Juan R, Viedma E, Chaves F, Lalueza A, Fortún J, Loza E, et al. High MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus. Emerging Infect Dis. 2016; 22(6):1057-66es
dc.identifier.doi10.3201/eid2206.151709
dc.identifier.essn1080-6059
dc.identifier.issn1080-6040
dc.identifier.pmcPMC4880091
dc.identifier.pmid27192097
dc.identifier.urihttp://hdl.handle.net/10668/2534
dc.journal.titleEmerging Infectious Diseases
dc.language.isoen
dc.publisherCenters for Disease Control and Preventiones
dc.relation.publisherversionhttp://wwwnc.cdc.gov/eid/article/22/6/15-1709_articlees
dc.rights.accessRightsopen access
dc.subjectCRBIes
dc.subjectMICes
dc.subjectMSSAes
dc.subjectbacteriaes
dc.subjectCatheter-related bloodstream infectiones
dc.subjectComplicated bacteremiaes
dc.subjectDaptomycines
dc.subjectMethicillin-sensitive Staphylococcus aureuses
dc.subjectSeptic thrombophlebitises
dc.subjectVancomycines
dc.subjectBacteriemiaes
dc.subjectInfecciones relacionadas con catétereses
dc.subjectDaptomicinaes
dc.subjectMeticilinaes
dc.subjectAnálisis multivariantees
dc.subjectOxacilinaes
dc.subjectVancomicinaes
dc.subject.meshMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Bacteremiaes
dc.subject.meshMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Catheter-Related Infectionses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclic::Daptomycines
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins::Methicillines
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Microbiological Techniques::Microbial Sensitivity Testses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Analysis of Variance::Multivariate Analysises
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Lactams::beta-Lactams::Penicillins::Oxacillines
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factorses
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europe::Spaines
dc.subject.meshMedical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Gram-Positive Bacterial Infections::Staphylococcal Infectionses
dc.subject.meshMedical Subject Headings::Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Staphylococcaceae::Staphylococcus::Staphylococcus aureuses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Glycoconjugates::Glycopeptides::Vancomycines
dc.titleHigh MICs for Vancomycin and Daptomycin and Complicated Catheter-Related Bloodstream Infections with Methicillin-Sensitive Staphylococcus aureus.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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