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Genetic copy number variants, cognition and psychosis: a meta-analysis and a family study.

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dc.contributor.authorThygesen, Johan H
dc.contributor.authorPresman, Amelia
dc.contributor.authorHarju-Seppänen, Jasmine
dc.contributor.authorIrizar, Haritz
dc.contributor.authorJones, Rebecca
dc.contributor.authorKuchenbaecker, Karoline
dc.contributor.authorLin, Kuang
dc.contributor.authorAlizadeh, Behrooz Z
dc.contributor.authorAustin-Zimmerman, Isabelle
dc.contributor.authorBartels-Velthuis, Agna
dc.contributor.authorBhat, Anjali
dc.contributor.authorBruggeman, Richard
dc.contributor.authorCahn, Wiepke
dc.contributor.authorCalafato, Stella
dc.contributor.authorCrespo-Facorro, Benedicto
dc.contributor.authorde Haan, Liewe
dc.contributor.authorde Zwarte, Sonja M C
dc.contributor.authorDi Forti, Marta
dc.contributor.authorDíez-Revuelta, Álvaro
dc.contributor.authorHall, Jeremy
dc.contributor.authorHall, Mei-Hua
dc.contributor.authorIyegbe, Conrad
dc.contributor.authorJablensky, Assen
dc.contributor.authorKahn, Rene
dc.contributor.authorKalaydjieva, Luba
dc.contributor.authorKravariti, Eugenia
dc.contributor.authorLawrie, Stephen
dc.contributor.authorLuykx, Jurjen J
dc.contributor.authorMata, Igancio
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorMcQuillin, Andrew
dc.contributor.authorMuir, Rebecca
dc.contributor.authorOphoff, Roel
dc.contributor.authorPicchioni, Marco
dc.contributor.authorPrata, Diana P
dc.contributor.authorRanlund, Siri
dc.contributor.authorRujescu, Dan
dc.contributor.authorRutten, Bart P F
dc.contributor.authorSchulze, Katja
dc.contributor.authorShaikh, Madiha
dc.contributor.authorSchirmbeck, Frederike
dc.contributor.authorSimons, Claudia J P
dc.contributor.authorToulopoulou, Timothea
dc.contributor.authorvan Amelsvoort, Therese
dc.contributor.authorvan Haren, Neeltje
dc.contributor.authorvan Os, Jim
dc.contributor.authorvan Winkel, Ruud
dc.contributor.authorVassos, Evangelos
dc.contributor.authorWalshe, Muriel
dc.contributor.authorWeisbrod, Matthias
dc.contributor.authorZartaloudi, Eirini
dc.contributor.authorBell, Vaughan
dc.contributor.authorPowell, John
dc.contributor.authorLewis, Cathryn M
dc.contributor.authorMurray, Robin M
dc.contributor.authorBramon, Elvira
dc.date.accessioned2023-02-09T09:37:33Z
dc.date.available2023-02-09T09:37:33Z
dc.date.issued2020-07-27
dc.description.abstractThe burden of large and rare copy number genetic variants (CNVs) as well as certain specific CNVs increase the risk of developing schizophrenia. Several cognitive measures are purported schizophrenia endophenotypes and may represent an intermediate point between genetics and the illness. This paper investigates the influence of CNVs on cognition. We conducted a systematic review and meta-analysis of the literature exploring the effect of CNV burden on general intelligence. We included ten primary studies with a total of 18,847 participants and found no evidence of association. In a new psychosis family study, we investigated the effects of CNVs on specific cognitive abilities. We examined the burden of large and rare CNVs (>200 kb, 200 kb,
dc.identifier.doi10.1038/s41380-020-0820-7
dc.identifier.essn1476-5578
dc.identifier.pmcPMC8589646
dc.identifier.pmid32719466
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8589646/pdf
dc.identifier.unpaywallURLhttps://www.nature.com/articles/s41380-020-0820-7.pdf
dc.identifier.urihttp://hdl.handle.net/10668/16010
dc.issue.number9
dc.journal.titleMolecular psychiatry
dc.journal.titleabbreviationMol Psychiatry
dc.language.isoen
dc.organizationInstituto de Biomedicina de Sevilla-IBIS
dc.organizationHospital Universitario Virgen del Rocío
dc.page.number5307-5319
dc.pubmedtypeJournal Article
dc.pubmedtypeMeta-Analysis
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeSystematic Review
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject.meshCognition
dc.subject.meshDNA Copy Number Variations
dc.subject.meshGenetic Predisposition to Disease
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshPsychotic Disorders
dc.subject.meshSchizophrenia
dc.titleGenetic copy number variants, cognition and psychosis: a meta-analysis and a family study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number26
dspace.entity.typePublication

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