Publication: Second-generation preimplantation genetic testing for aneuploidy in assisted reproduction: a SWOT analysis.
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2019-08-13
Authors
Bellver, José
Bosch, Ernesto
Espinós, Juan José
Fabregues, Francisco
Fontes, Juan
García-Velasco, Juan
Llácer, Joaquín
Requena, Antonio
Checa, Miguel Angel
Spanish Infertility SWOT Group (SISG)
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Abstract
Second-generation preimplantation genetic testing for aneuploidy (PGT-A 2.0) in patients with an unfavourable reproductive and IVF prognosis is becoming common practice, with the aim of improving reproductive outcomes. However, there is still no clear evidence on the possible advantages and drawbacks with regard to this procedure. In this discussion paper, based on a SWOT (strengths, weaknesses, opportunities, threats) analysis, the different aspects of this strategy are evaluated. Current evidence suggests that PGT-A 2.0 should not at present have an indiscriminate application, but it might be indicated in cases in which the risk of aneuploidy is increased.
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MeSH Terms
Abortion, Spontaneous
Aneuploidy
Female
Genetic Testing
Humans
Pregnancy
Pregnancy Rate
Preimplantation Diagnosis
Aneuploidy
Female
Genetic Testing
Humans
Pregnancy
Pregnancy Rate
Preimplantation Diagnosis
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Keywords
Assisted reproduction, Blastocyst biopsy, Implantation, Infertility, Live birth, Preimplantation genetic testing