Editorial: Regulation of AMPA Receptors, From the Genetic to the Functional Level.

Abstract

AMPA receptors (AMPARs) are widely distributed in the central and peripheral nervous systems. They are mainly located in postsynaptic cells, but can also be found in pre-synaptic sites and glia processes. Upon glutamate stimulation, the postsynaptic AMPARs mediate the fast excitatory synaptic transmission which can be changed in an activity dependent manner and might involve a minority of Ca2+ permeable AMPARs. This Research Topic describes several new mechanisms that regulate AMPAR trafficking and plasticity; in addition to give novel insight to the function of AMPAR in the hypothalamus.