Antiphospholipid antibodies negativization: time for testing for non-criteria aPL?

Abstract

Sir,While we read with interest the recent article byComarmond and colleagues 1 about the cessation oforal anticoagulants in antiphospholipid syndrome(APS), we do feel there are some points of the studystill open for discussion.Comarmond and colleagues 1 describe 10 patientswith prolonged disappearance of antiphospholipidantibodies (aPL) that were stopped anticoagulationtherapy. After a median duration of follow-up of 19months since the cessation of oral anticoagulants,one out of 10 patients relapsed developing pulmon-ary embolism.