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Decreasing and stabilising trends of antimicrobial consumption and resistance in Escherichia coli and Klebsiella pneumoniae in segmented regression analysis, European Union/European Economic Area, 2001 to 2018.

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Date

2019

Authors

Peñalva, Germán
Högberg, Liselotte Diaz
Weist, Klaus
Vlahović-Palčevski, Vera
Heuer, Ole
Monnet, Dominique L
ESAC-Net study group
EARS-Net study group

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Abstract

Investments to reduce the spread of antimicrobial resistance (AMR) in the European Union have been made, including efforts to strengthen prudent antimicrobial use. Using segmented regression, we report decreasing and stabilising trends in data reported to the European Surveillance of Antimicrobial Consumption Network and stabilising trends in data reported to the European Antimicrobial Resistance Surveillance Network. Our results could be an early indication of the effect of prioritising AMR on the public health agenda.

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Anti-Bacterial Agents
Antimicrobial Stewardship
Cephalosporins
Drug Resistance, Multiple, Bacterial
Drug Utilization
Escherichia coli
Escherichia coli Infections
European Union
Fluoroquinolones
Humans
Klebsiella Infections
Klebsiella pneumoniae
Microbial Sensitivity Tests
Population Surveillance

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Keywords

Antimicrobial consumption, Escherichia coli, Klebsiella pneumoniae, antimicrobial resistance, bacterial infections, carbapenem, defined daily dose, fluoroquinolone, third-generation cephalosporin

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