Publication:
Prognosis Relevance of Serum Cytokines in Pancreatic Cancer.

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dc.contributor.authorTorres, Carolina
dc.contributor.authorLinares, Ana
dc.contributor.authorAlejandre, Maria José
dc.contributor.authorPalomino-Morales, Rogelio J
dc.contributor.authorCaba, Octavio
dc.contributor.authorPrados, Jose
dc.contributor.authorAránega, Antonia
dc.contributor.authorDelgado, Juan R
dc.contributor.authorIrigoyen, Antonio
dc.contributor.authorMartínez-Galán, Joaquina
dc.contributor.authorOrtuño, Francisco M
dc.contributor.authorRojas, Ignacio
dc.contributor.authorPerales, Sonia
dc.contributor.authoraffiliation[Torres,C; Linares,A; Alejandre,MJ; Palomino-Morales,RJ; Perales,S] Department of Biochemistry and Molecular Biology I, University of Granada, Granada, Spain. [Caba,O] Department of Health Sciences, University of Jaen, Jaen, Spain. [Prados,J; Aránega,A] Department of Human Anatomy and Embryology, University of Granada, Granada, Spain. [Delgado,JR; Irigoyen,A; Martínez-Galán,J] Oncology Service, Virgen de las Nieves Hospital, Granada, Spain. [Ortuño,FM; Rojas,I] Department of Computer Architecture and Computer Technology (CITIC-UGR), University of Granada, Granada, Spaines
dc.contributor.funderThe study was fully supported by ROCHE FARMA S.A (ref.H/OH-TAR-10/131 and ref. H/OH-TRR-08/59) and Instituto de Salud Carlos III (ISCIII) (Clinical trial ref. EC08/00009),and the Government of Andalusia Project P12-TIC-2082
dc.date.accessioned2015-11-27T13:38:48Z
dc.date.available2015-11-27T13:38:48Z
dc.date.issued2015
dc.descriptionJournal Article;es
dc.description.abstractThe overall survival of patients with pancreatic ductal adenocarcinoma is extremely low. Although gemcitabine is the standard used chemotherapy for this disease, clinical outcomes do not reflect significant improvements, not even when combined with adjuvant treatments. There is an urgent need for prognosis markers to be found. The aim of this study was to analyze the potential value of serum cytokines to find a profile that can predict the clinical outcome in patients with pancreatic cancer and to establish a practical prognosis index that significantly predicts patients' outcomes. We have conducted an extensive analysis of serum prognosis biomarkers using an antibody array comprising 507 human cytokines. Overall survival was estimated using the Kaplan-Meier method. Univariate and multivariate Cox's proportional hazard models were used to analyze prognosis factors. To determine the extent that survival could be predicted based on this index, we used the leave-one-out cross-validation model. The multivariate model showed a better performance and it could represent a novel panel of serum cytokines that correlates to poor prognosis in pancreatic cancer. B7-1/CD80, EG-VEGF/PK1, IL-29, NRG1-beta1/HRG1-beta1, and PD-ECGF expressions portend a poor prognosis for patients with pancreatic cancer and these cytokines could represent novel therapeutic targets for this disease.es
dc.description.versionYeses
dc.identifier.citationTorres C, Linares A, Alejandre MJ, Palomino-Morales RJ, Caba O, Prados J, et al. Prognosis Relevance of Serum Cytokines in Pancreatic Cancer. Biomed Res Int; 2015:518284es
dc.identifier.doi10.1155/2015/518284
dc.identifier.essn2314-6141
dc.identifier.pmcPMC4539422
dc.identifier.pmid26346854
dc.identifier.urihttp://hdl.handle.net/10668/2089
dc.journal.titleBioMed research international
dc.language.isoen
dc.publisherHindawi Publishing Corporationes
dc.relation.publisherversionhttp://www.hindawi.com/journals/bmri/2015/518284/abs/es
dc.rights.accessRightsopen access
dc.subjectMarcadores biológicoses
dc.subjectCarcinoma ductal pancreáticoes
dc.subjectCitocinases
dc.subjectDesoxicitidinaes
dc.subjectHumanoses
dc.subjectNeoplasias pancreáticases
dc.subjectPronósticoes
dc.subjectModelos de riesgos proporcionaleses
dc.subjectTimidina fosforilasaes
dc.subjectFactor de crecimiento endotelial vascular derivado de glándulas endocrinases
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markerses
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Pancreatic Neoplasms::Carcinoma, Pancreatic Ductales
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokineses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidine Nucleosides::Cytidine::Deoxycytidinees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Pancreatic Neoplasmses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosises
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Models, Statistical::Proportional Hazards Modelses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Glycosyltransferases::Pentosyltransferases::Pyrimidine Phosphorylases::Thymidine Phosphorylasees
dc.titlePrognosis Relevance of Serum Cytokines in Pancreatic Cancer.es
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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