Publication:
Hyperelastic Ex Vivo Cervical Tissue Mechanical Characterization

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Date

2020-08-05

Authors

Callejas, Antonio
Melchor, Juan
Faris, Inas H.
Rus, Guillermo

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MDPI
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Abstract

This paper presents the results of the comparison between a proposed Fourth Order Elastic Constants (FOECs) nonlinear model defined in the sense of Landau's theory, and the two most contrasted hyperelastic models in the literature, Mooney-Rivlin, and Ogden models. A mechanical testing protocol is developed to investigate the large-strain response of ex vivo cervical tissue samples in uniaxial tension in its two principal anatomical locations, the epithelial and connective layers. The final aim of this work is to compare the reconstructed shear modulus of the epithelial and connective layers of cervical tissue. According to the obtained results, the nonlinear parameter A from the proposed FOEC model could be an important biomarker in cervical tissue diagnosis. In addition, the calculated shear modulus depended on the anatomical location of the cervical tissue (μepithelial = 1.29 ± 0.15 MPa, and μconnective = 3.60 ± 0.63 MPa).

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Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Elasticity
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Phenomena and Processes::Physical Phenomena::Mechanical Phenomena::Mechanical Processes::Stress, Mechanical
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models, Theoretical::Nonlinear Dynamics
Medical Subject Headings::Diseases::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::Uterine Diseases::Uterine Cervical Diseases
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markers

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Keywords

Hyperelasticity, Uniaxial tensile test, Cervical tissue, Nonlinearity, Hyperelastic models, Dinámicas no lineales, Enfermedades del cuello del útero, Pruebas mecánicas, Biomarcadores, Elasticidad, Tejidos

Citation

Callejas A, Melchor J, Faris IH, Rus G. Hyperelastic Ex Vivo Cervical Tissue Mechanical Characterization. Sensors. 2020 Aug 5;20(16):4362