Publication:
Real-world clinical experience of dupilumab in the treatment of chronic palmo-plantar eczema in patients with moderate-severe atopic dermatitis: 52-week follow-up

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Date

2024-02-19

Authors

Navarro-Triviño, Francisco José
Armario-Hita, José Carlos
Ruiz-Villaverde, Ricardo
Domínguez-Cruz, Javier
Pereyra-Rodriguez, Jose Juan

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Mary Ann Liebert, Inc Publishers
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Abstract

Background: Hand-foot eczema (HFE) are special locations of dermatitis, which are often associated with atopic dermatitis (AD) and have a significant negative impact on the quality of life, demanding a clinically relevant improvement. Objectives: To evaluate the effectiveness and safety of dupilumab in the treatment of eczema localized in hands and/or feet in patients with moderate-to-severe AD. Methods: Retrospective multicenter study of adult patients with HFE treated with dupilumab for their AD. Patients with other concomitantly systemic immunosuppressive treatments did not undergo a washout period. The severity of palmar and/or plantar involvement was assessed using the Physician Global Assessment (PGA) scale on a scale of 0 ( = clear) to 5 ( = very severe). Eczema Area and Severity Index (EASI) and NRS-pruritus scales were also evaluated. One hundred percent of patients reached week 16, while 67/84 reached week 52 of follow-up. Results: A total of 84 patients were included 86.69% of patients showed a reduction in PGA-Hand, and 80.34% in PGA-Foot at week 52, EASI improvement was reached by 83.55% of patients at week 16 and 87.35% at week 52. Reduction of pruritus (≥4 points in NRS-pruritus scale) was 73.01% at week 16 and 80.67% at week 52. No differences in response to dupilumab were observed in the different subtypes of palmo-plantar dermatitis. Conclusions: The results obtained in our study suggest that dupilumab may be an effective and safe therapeutic option for the treatment of dermatitis localized in hands and/or feet.

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MeSH Terms

Dermatitis, Atopic
Eczema
Hands
Feet
Antibodies, Monoclonal, Humanized

DeCS Terms

Dermatitis Atópica
Eccema
Manos
Pies
Anticuerpos Monoclonales Humanizados

CIE Terms

Keywords

Dupilumab, Atopic Dermatitis, Hand Eczema, Foot Eczema, Real-world Evidence

Citation

Navarro-Triviño FJ, Galán-Gutiérrez M, Hita JC, Ruiz-Villaverde R, Domínguez-Cruz J, Pereyra-Rodríguez JJ. Real-World Clinical Experience of Dupilumab in the Treatment of Chronic Palmo-Plantar Eczema in Patients with Moderate-Severe Atopic Dermatitis: 52-Week Follow-Up. Dermatitis. 2024 Jan-Feb;35(S1):S55-S61